- Aminomethylation of Thiourea with Formaldehyde and Cyclic Amines
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Three-component condensation of thiourea with equimolar amounts of formaldehyde and morpholine afforded N-(morpholin-4-ylmethyl) derivative, whereas analogous reaction with 2 equiv of formaldehyde and amine gave symmetrical N,N′-bis(morpholin-4-ylmethyl)thiourea. In the condensation of thiourea with piperidine and formaldehyde, only symmetrical N,N′-bis(piperidin-1-ylmethyl)thiourea was isolated, regardless of the reactant ratio.
- Martinovich, Yu. A.,Ramsh,Hamoud,Fundamenskii,Gurzhii,Zakharov,Khrabrova
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p. 878 - 885
(2018/07/31)
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