75172-66-6

Basic information

• Product Name: L-4-methoxymandelic acid
• Synonyms: L-4-methoxymandelic acid;(S)-2-Hydroxy-2-(4-Methoxyphenyl)acetic acid
• CAS NO: 75172-66-6
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.174
• Mol File: 75172-66-6.mol

Chemical Properties

• Melting Point: 105-106℃
• Boiling Point: 370.4 °C at 760 mmHg
• Flash Point: 152.6 °C
• Appearance: /
• Density: 1.309
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: L-4-methoxymandelic acid(CAS DataBase Reference)
• NIST Chemistry Reference: L-4-methoxymandelic acid(75172-66-6)
• EPA Substance Registry System: L-4-methoxymandelic acid(75172-66-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 75172-66-6(Hazardous Substances Data)

Usage

Chemical Properties

White crystal

Upstream product

• 7099-91-4 p-methoxybenzoylformic acid 
• 32766-61-3 4-methoxyphenylglyoxylate methyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 20714-90-3 4-Methoxymandelic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 108-05-4 vinyl acetate 
• 77-78-1 dimethyl sulfate 
• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 

Downstream Products

• 104383-29-1 methyl (S)-α-hydroxy-(4-methoxyphenyl)acetate 

Relevant articles and documents

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

Asymmetric hydrogenation reaction of alpha-ketoacids compound

The invention relates to the technical field of organic chemistry, especially to an asymmetric hydrogenation reaction of an alpha-ketoacids compound. The asymmetric hydrogenation reaction comprises a scheme shown in the description. In the scheme, R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, C1-C6 alkyl, or aralkyl; a substituent group is C1-C6 alkyl, C1-C6 alkoxy, or halogen; and the number of the substituent group is 1-3. In the scheme, M is a chiral spiro-pyridylamino phosphine ligand iridium complex having a structure shown in the description. In the structure, R is hydrogen, 3-methyl, 4-tBu, or 6-methyl.

Resolving synthetic method for paramethoxymandelic acid

The present invention relates to a resolving synthetic method for paramethoxymandelic acid. The method comprises the following steps of: by taking chiral alpha-phenylethylamine acid as a resolving agent, carrying out a salt forming reaction on the paramet

Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.

A new system for the reduction of 4-hydroxymandelic acids

We describe a new reduction of 4-hydroxymandelic acids which is easy to perform with available, cheap and environmentally clean reagents.The reduction of these acids is an important method for the synthesis of (4-hydroxyphenyl)-acetic acids.The new reducing system is constituted of sodium bisulfite or dithionite in catalytic quantities and formic acid in slight excess. - Keywords: 4-hydroxymandelic acid; reduction; sodium bisulfite; sodium dithionite; formic acid