768404-03-1

Basic information

• Product Name: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one
• Synonyms: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one;5-BDBD
• CAS NO: 768404-03-1
• Molecular Formula: C17H11BrN2O2
• Molecular Weight: 355
• Mol File: 768404-03-1.mol

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: Store at RT
• Solubility: DMSO: soluble15mg/mL (clear solution)
• CAS DataBase Reference: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one(768404-03-1)
• EPA Substance Registry System: 5-(3-Bromophenyl)-1,3-dihydro-2H-benzofuro[3,2-e]-1,4-diazepin-2-one(768404-03-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• Hazardous Substances Data: 768404-03-1(Hazardous Substances Data)

Usage

Uses

5-BDBD is a potent P2X4 receptor antagonist.

Biochem/physiol Actions

5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC50 of 500 nM.

Upstream product

• 768404-05-3 (3-aminobenzofuran-2-yl)-(3-bromophenyl)methanone 
• 611-20-1 salicylonitrile 
• 18523-22-3 2,3'-dibromoacetophenone 
• 1457216-73-7 C₁₅H₁₀BrNO₂ 

Relevant articles and documents

Synthesis and preliminary biological evaluation of radiolabeled 5-BDBD analogs as new candidate PET radioligands for P2X4 receptor

P2X4 receptor has become an interesting molecular target for treatment and PET imaging of neuroinflammation and associated brain diseases such as Alzheimer's disease. This study reports the first design, synthesis, radiolabeling and biological evaluation

BENZOFURO-1,4-DIAZEPIN-2-ONE DERIVATIVES

The invention relates to novel benzofuro-1,4-diazepin-2-one derivatives, to a method for producing said derivatives and to their use as P2X4 receptor antagonists for producing medicaments for the treatment and/or prophylaxis of diseases, in par