769159-85-5

Basic information

• Product Name: 4-cyclopropyl-1-fluoro-2-nitrobenzene
• Synonyms: 4-cyclopropyl-1-fluoro-2-nitrobenzene
• CAS NO: 769159-85-5
• Molecular Formula: C₉H₈FNO₂
• Molecular Weight: 181.1637232
• Mol File: 769159-85-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-cyclopropyl-1-fluoro-2-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-cyclopropyl-1-fluoro-2-nitrobenzene(769159-85-5)
• EPA Substance Registry System: 4-cyclopropyl-1-fluoro-2-nitrobenzene(769159-85-5)

Safety Data

• Hazardous Substances Data: 769159-85-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-Cyclopropyl-1-fluoro-2-nitrobenzene is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure, including the cyclopropyl, fluorine, and nitro groups, allows for the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Research:
4-Cyclopropyl-1-fluoro-2-nitrobenzene is used as a research compound in the field of organic chemistry. Its properties and reactivity can be studied to understand the effects of different functional groups on the benzene ring, which can lead to the development of new synthetic methods and applications.
Used in Material Science:
4-Cyclopropyl-1-fluoro-2-nitrobenzene is used as a building block in the development of new materials with specific properties. Its incorporation into polymers or other materials can result in unique characteristics, such as improved stability, enhanced reactivity, or altered physical properties, which can be beneficial in various applications.

Upstream product

• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 411235-57-9 cyclopropylboronic acid 
• 364-75-0 1-fluoro-4-iodo-2-nitro-benzene 
• 23719-81-5 tri(cyclopropyl)indium 

Downstream Products

• 769159-82-2 4-cyclopropyl-2-nitro-N-(3-(3-pyridyl)phenyl)aniline 
• 1374298-69-7 5-cyclopropyl-2-fluoroaniline 

Relevant articles and documents

Facile synthesis of aryl(het)cyclopropane catalyzed by palladacycle

Sphos (2-dicyclohexylphosphino-2′,6′-dimethoxy-1,1′- biphenyl) adduct of cyclopalladated ferrocenylimine (IIe) exhibited highly catalytic activity for the Suzuki cross-coupling reaction of cyclopropylboronic acid with aryl(het) halides with 1 mol % catalyst loading. This process was applied to both of aryl and heteroaryl halides (Br and Cl), and made the various arylcyclopropane and heteroarylcyclopropane to be easily synthesized. A variety of substituents on the aryl halides, such as alkyl, acetyl, benzoyl, ether, formyl, carboxylate, methoxy, nitro and cyano were tolerated.

Tricyclic Compounds As mPGES-1 Inhibitors

The present invention relates to tricyclic compounds of formula (I) or pharmaceutically acceptable salt thereof as mPGES-1 inhibitors. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful in the treatment of pain and/or inflammation from a variety of diseases or conditions, such as asthma, osteoarthritis, rheumatoid arthritis, acute or chronic pain and neurodegenerative diseases.

BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX

This invention relates to novel benzimidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.