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CAS

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78287-26-0

7-METHYL CAMPTOTHECIN is a poorly water-soluble camptothecin analogue, which is a type of chemical compound derived from the Camptotheca tree. It is a yellow solid with significant potential in the field of cancer treatment due to its ability to act as a DNA topoisomerase I inhibitor.

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  • 78287-26-0 Structure

  • Basic information

    1. Product Name: 7-METHYL CAMPTOTHECIN
    2. Synonyms: 7-METHYL CAMPTOTHECIN
    3. CAS NO:78287-26-0
    4. Molecular Formula: C21H18N2O4
    5. Molecular Weight: 362.37862
    6. EINECS: N/A
    7. Product Categories: Chiral Reagents;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
    8. Mol File: 78287-26-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: DMSO
    9. CAS DataBase Reference: 7-METHYL CAMPTOTHECIN(CAS DataBase Reference)
    10. NIST Chemistry Reference: 7-METHYL CAMPTOTHECIN(78287-26-0)
    11. EPA Substance Registry System: 7-METHYL CAMPTOTHECIN(78287-26-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 78287-26-0(Hazardous Substances Data)

78287-26-0 Usage

Uses

Used in Pharmaceutical Industry:
7-METHYL CAMPTOTHECIN is used as an antitumor agent for its potential in cancer treatment. It functions as a DNA topoisomerase I inhibitor, which can help in the development of new camptothecin derivatives with improved efficacy and reduced side effects.
Used in Drug Design and Development:
7-METHYL CAMPTOTHECIN is used as a reference compound in the design and development of new camptothecin derivatives. Its properties and interactions with DNA topoisomerase I can provide valuable insights for creating more effective and targeted cancer treatments.
Used in QSAR Studies:
7-METHYL CAMPTOTHECIN is utilized in quantitative structure-activity relationship (QSAR) studies to understand the relationship between the chemical structure of camptothecin analogues and their biological activity as DNA topoisomerase I inhibitors. This information can be crucial for the development of more potent and selective anticancer drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 78287-26-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,2,8 and 7 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 78287-26:
(7*7)+(6*8)+(5*2)+(4*8)+(3*7)+(2*2)+(1*6)=170
170 % 10 = 0
So 78287-26-0 is a valid CAS Registry Number.

78287-26-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-Methylcamptothecin

1.2 Other means of identification

Product number -
Other names 7-Methyl Camptothecin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78287-26-0 SDS

78287-26-0Downstream Products

78287-26-0Relevant articles and documents

Novel route for preparation of 7-methyl-camptothecin and its possible mechanism

Wang, Xin,Wen, Jiwu,Li, Gang,You, Tianpa

, p. 3163 - 3166 (2005)

A novel route for preparation of 7-methyl-camptothecin is described. Its possible mechanism is discussed. Copyright Taylor & Francis, Inc.

Chemical modification of an antitumor alkaloid camptothecin: Synthesis and antitumor activity of 7-C-substituted camptothecins

Sawada,Nokata,Furuta,Yokokura,Miyasaka

, p. 2574 - 2580 (2007/10/02)

A radical substitution reaction of 20(S)-camptothecin (1) with methanol furnished 7-hydroxymethylcamptothecin (2). Reaction of 1 with primary alcohols higher than methanol gave 7-alkylcamptothecins (4), of which alkyl groups were one carbon less than the alcohols used and also 7-hydroxyalkylcamptothecins (5). For the preparation of 7-alkylcamptothecin (4), aldehydes were used as a radical source and several alkylated derivatives were synthesized. 7-Acyloxymethyl derivatives (6), 7-carbaldehyde (7), iminomethyl derivatives (10), acid (11), esters (12) and amides (13) were synthesized starting from 2. 7-Ethyl- (4b) and 7-propylcamptothecin (4c), acyloxymethyl compounds 6a, 6c and ethyl ester (12b) exhibited higher antitumor activity than 1 against L1210 in mice.

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