786600-48-4

Basic information

• Product Name: 2-AMINO-1-(3,4-DIMETHYLPHENYL)ETHANOL
• Synonyms: 2-AMINO-1-(3,4-DIMETHYLPHENYL)ETHANOL;alpha-(Aminomethyl)-3,4-dimethylbenzenemethanol;2-AMino-1-(3,4-diMethylphenyl)ethanol HCl
• CAS NO: 786600-48-4
• Molecular Formula: C10H15NO
• Molecular Weight: 165.234
• Mol File: 786600-48-4.mol

Chemical Properties

• Boiling Point: 318.335 °C at 760 mmHg
• Flash Point: 146.324 °C
• Appearance: /
• Density: 1.054
• CAS DataBase Reference: 2-AMINO-1-(3,4-DIMETHYLPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-1-(3,4-DIMETHYLPHENYL)ETHANOL(786600-48-4)
• EPA Substance Registry System: 2-AMINO-1-(3,4-DIMETHYLPHENYL)ETHANOL(786600-48-4)

Safety Data

• Hazardous Substances Data: 786600-48-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-amino-1-(3,4-dimethylphenyl)ethanol is used as a precursor in the synthesis of various pharmaceuticals and organic compounds. Its structural features, including the presence of an amino group and a hydroxyl group, make it a valuable intermediate for the development of new drugs and chemical entities.
Used in Medicinal Chemistry and Drug Development:
Due to its unique structural features, 2-amino-1-(3,4-dimethylphenyl)ethanol has potential applications in the field of medicinal chemistry and drug development. Researchers can utilize 2-amino-1-(3,4-dimethylphenyl)ethanol as a starting material or a building block to design and synthesize novel therapeutic agents with improved pharmacological properties.
Used in Biological Activities and Therapeutic Properties Research:
2-amino-1-(3,4-dimethylphenyl)ethanol has been studied for its potential biological activities and therapeutic properties. Its unique structure may contribute to its ability to interact with biological targets, such as enzymes, receptors, or other macromolecules, leading to potential applications in the treatment of various diseases and conditions.

InChI:InChI=1S/C10H15NO/c1-7-3-4-9(5-8(7)2)10(12)6-11/h3-5,10,12H,6,11H2,1-2H3

Upstream product

• 5973-71-7 3,4-dimethylbenzaldehyde 
• 854179-33-2 1-(3,4-dimethylphenyl)-2-nitroethan-1-ol 
• 3637-01-2 3,4-dimethylacetophenone 
• 95-47-6 o-xylene 
• 20973-21-1 ω-(dibenzylamino)-3,4-dimethylacetophenone 
• 2633-50-3 2-bromo-1-(3,4-dimethylphenyl)ethanone 
• 112689-10-8 (3,4-dimethyl-phenyl)-glyoxal-2-oxime 
• 20973-37-9 1-(3,4-dimethylphenyl)-2-dibenzylaminoethanol 

Relevant articles and documents

Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides

CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). A series of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides have been synthesised using an efficient synthetic route and shown to be potent inhibitors of CYP24A1 (IC50 0.11–0.35?μM) compared with the standard ketoconazole. Molecular modelling using our CYP24A1 homology model showed the inhibitors to fill the hydrophobic binding site, forming key transition metal interaction between the imidazole nitrogen and the haem Fe3+ and multiple interactions with the active site amino acid residues.

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrebergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs

In order to contribute to the definition of the role played by the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity, certain 3-phenyl-3-piperidinols (PPOs, 4) and their corresponding desoxy 3-phenylpiperidine analogs (PPEs, 6) were synthesized and tested for their α1- and α2-adrenergic activity by means of functional tests on isolated preparations.As regards the α1-adrenergic activity, the values of the activity indices of the cyclic catecholic compounds (PPO 4a and PPE 6a) indicate that the benzylic hydroxyl does notplay an essential role, provided that the other two active groups are in the pharmacophoric conformation.However, the fact that none of the other non-catecholic cyclic analogs are active on the α1-receptor does not allow us to generalize this observation.As regards the α2-adrenergic activity, the high values of the activity indices of PPEs 6, compared with those of the corresponding 1-phenyl-2-aminoethanols (PAEs,3), PPPOs (4) and 2-phenylethylamines (PEAs,5), confirm that when the aromatic moiety and the amino group are constrained into the pharmacophoric relationship, the presence of the alcoholic hydroxyl is not only unnecessary for the purposes of the expression of the activity at the level of the α2-adrenoceptor, but often has negative effect. adrenergic drug / 3-phenyl-3-piperidinol / 3-phenylpiperidine / 1-phenyl-2-aminoethanol / 2-phenylethylamine / α1-adrenergic agonist activity / α2-adrenergic agonist activity