78686-83-6

Basic information

• Product Name: METHYL 2-CHLORO-5-IODONICOTINATE
• Synonyms: METHYL 2-CHLORO-5-IODONICOTINATE;Methyl 2-chloro-5-iodopyridine-3-carboxylate
• CAS NO: 78686-83-6
• Molecular Formula: C₇H₅ClINO₂
• Molecular Weight: 297.48
• Mol File: 78686-83-6.mol

Chemical Properties

• Melting Point: 70-73°
• Boiling Point: 329°C at 760 mmHg
• Flash Point: 152.7°C
• Appearance: /
• Density: 1.924g/cm³
• Vapor Pressure: 0.000183mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: METHYL 2-CHLORO-5-IODONICOTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-CHLORO-5-IODONICOTINATE(78686-83-6)
• EPA Substance Registry System: METHYL 2-CHLORO-5-IODONICOTINATE(78686-83-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 78686-83-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
METHYL 2-CHLORO-5-IODONICOTINATE is used as a building block in organic synthesis reactions for the preparation of complex molecules, particularly in the synthesis of pharmaceuticals and agrochemicals. Its unique halogenated structure allows for the creation of diverse chemical entities with potential therapeutic and agricultural applications.
Used in Research and Development Laboratories:
METHYL 2-CHLORO-5-IODONICOTINATE is employed as a valuable tool in research and development laboratories, where it is utilized for its versatile applications in drug discovery and material science. Its unique properties and reactivity make it an essential component in the development of new compounds and materials with improved properties and functionalities.

InChI:InChI=1/C7H5ClINO2/c1-12-7(11)5-2-4(9)3-10-6(5)8/h2-3H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 59782-86-4 2-chloro-5-iodonicotinic acid 
• 116387-40-7 methyl 2-hydroxy-5-iodopyridine-3-carboxylate 
• 609-71-2 1,2-dihydro-2-oxonicotinic acid 
• 10128-91-3 methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile 
• 10128-91-3 methyl 2-hydroxynicotinate 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 116387-40-7 methyl 5-iodo-2-oxo-1,2-dihydro-3-pyridinecarboxylate 

Downstream Products

• 116387-41-8 methyl 5-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>-2-chloro-3-pyridinecarboxylate 
• 95693-76-8 (6RS)-5,10-dideaza-5,6,7,8-tetrahydrofolic acid 
• 116387-28-1 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxy-5,6,7,8-tetrahydropyrido<2,3-d>pyrimidin-6-yl>ethyl>benzoyl>-L-glutamate 
• 116387-38-3 2-amino-4-hydroxy-6-<(4-carbxyphenyl)ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-33-8 2-amino-4-hydroxy-6-<<4-(tert-butoxycarbonyl)phenyl>ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-35-0 2-(pivaloylamino)-4-hydroxy-6-<(carboxyphenyl)ethynyl>pyrido<2,3-d>pyrimidine 
• 116387-24-7 diethyl N-<4-<<2-(pivaloylamino)-4-hydroxypyrido<2,3-d>pyrimidin-6-yl>ethynyl>benzoyl>-L-glutamate 
• 1073230-38-2 methyl 2-{(3-ethoxy-3-oxopropanoyl)[4-(trifluoromethyl)benzyl]amino}-5-iodonicotinate 
• 1073230-39-3 ethyl 4-hydroxy-6-iodo-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridine-3-carboxylate 
• 1256794-68-9 methyl 2-chloro-5-ethynylpyridine-3-carboxylate 

Relevant articles and documents

AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.

QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE

Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.

Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.

Some Methyl 2,5- and 5,6-Dihalonicotinates

The preparation of the methyl esters of eight dihalonicotinic acids is described.The esters were synthesized either by the methanolysis of their respective acid chlorides or by treatment of the appropriate acid with diazomethane in ether.Experimental and spectral data for the methyl dihalonicotinates are presented.