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METHYL 2-CHLORO-5-IODONICOTINATE, a halogenated derivative of nicotinic acid with the molecular formula C7H6ClINO2, is a chemical compound that is commonly found in trace amounts in tobacco. It is a white to off-white solid at room temperature and is soluble in organic solvents such as ethanol and methanol. This versatile compound is primarily used in research and development laboratories for its applications in drug discovery and material science.

78686-83-6

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78686-83-6 Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
METHYL 2-CHLORO-5-IODONICOTINATE is used as a building block in organic synthesis reactions for the preparation of complex molecules, particularly in the synthesis of pharmaceuticals and agrochemicals. Its unique halogenated structure allows for the creation of diverse chemical entities with potential therapeutic and agricultural applications.
Used in Research and Development Laboratories:
METHYL 2-CHLORO-5-IODONICOTINATE is employed as a valuable tool in research and development laboratories, where it is utilized for its versatile applications in drug discovery and material science. Its unique properties and reactivity make it an essential component in the development of new compounds and materials with improved properties and functionalities.

Check Digit Verification of cas no

The CAS Registry Mumber 78686-83-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,6,8 and 6 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 78686-83:
(7*7)+(6*8)+(5*6)+(4*8)+(3*6)+(2*8)+(1*3)=196
196 % 10 = 6
So 78686-83-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H5ClINO2/c1-12-7(11)5-2-4(9)3-10-6(5)8/h2-3H,1H3

78686-83-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 2-chloro-5-iodonicotinate

1.2 Other means of identification

Product number -
Other names methyl 2-chloro-5-iodopyridine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78686-83-6 SDS

78686-83-6Relevant articles and documents

AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

-

, (2008/12/06)

Compounds of Formula (I) are useful as inhibitors of HIF prolyl hydroxylases where the definitions of the variables are provided herein.

QUINOLONES AND AZAQUINOLONES THAT INHIBIT PROLYL HYDROXYLASE

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, (2008/12/08)

Compounds of Formula I are useful inhibitors of HIF prolyl hydroxylases. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

Inhibitors of protein tyrosine phosphatase 1B

-

Page/Page column 13; 33, (2008/06/13)

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.

2-(Alkylamino)nicotinic Acid and Analogs. Potent Angiotensin II Antagonists

Winn, Martin,De, Biswanath,Zydowsky, Thomas M.,Altenbach, Robert J.,Basha, Fatima Z.,et al.

, p. 2676 - 2688 (2007/10/02)

A series of pyridines and other six-membered ring heterocycles connected to a biphenyltetrazole with a-CH2-NR'-link (1) were discovered to be potent angiotensin II antagonists.In the pyrimidine carboxylic acid series (W = CR, X = N, Y = CH, Z = COOH), compounds with an alkyl group (R') on the exocyclic nitrogen were much more potent than compounds with an alkyl group (R) on the heterocyclic ring.The corresponding pyridine, pyridazine, pyrazine, and 1,2,4-triazine carboxylic acids also showed potent in vitro angiotensin II antagonism.The pyridine (W, X, Y = CH, Z = COOH, R' = n-C3H7) demonstrated potent in vitro activity (pA2 = 10.10, rabbit aorta, and Ki = 0.61 nM, receptor binding in rat liver) as well as exceptional oral antihypertensive activity and bioavailability.Any nonacidic replacement for the carboxylic acid was detrimental for activity.

Angiotensin II receptor antagonists

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, (2008/06/13)

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.

Some Methyl 2,5- and 5,6-Dihalonicotinates

Setliff, Frank L.,Hule, W. Reeves

, p. 332 - 333 (2007/10/02)

The preparation of the methyl esters of eight dihalonicotinic acids is described.The esters were synthesized either by the methanolysis of their respective acid chlorides or by treatment of the appropriate acid with diazomethane in ether.Experimental and spectral data for the methyl dihalonicotinates are presented.

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