79491-48-8

Basic information

• Product Name: 2-Bromo-5,6-dimethoxy-3-nitropyridine
• Synonyms: 2-Bromo-5,6-dimethoxy-3-nitropyridine;4-Methoxy-2-Methyl-3-pyridinecarbonitrile;Pyridine, 2-broMo-5,6-diMethoxy-3-nitro-
• CAS NO: 79491-48-8
• Molecular Formula: C7H7BrN2O4
• Molecular Weight: 263.05
• Mol File: 79491-48-8.mol

Chemical Properties

• Melting Point: 142-143 °C(Solv: methanol (67-56-1))
• Boiling Point: 312.9±37.0 °C(Predicted)
• Appearance: /
• Density: 1.657
• PKA: -6.85±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5,6-dimethoxy-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5,6-dimethoxy-3-nitropyridine(79491-48-8)
• EPA Substance Registry System: 2-Bromo-5,6-dimethoxy-3-nitropyridine(79491-48-8)

Safety Data

• Hazardous Substances Data: 79491-48-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-5,6-dimethoxy-3-nitropyridine is used as a key intermediate in organic synthesis for the production of various drugs. Its unique structure allows for the development of new pharmaceutical compounds with potential therapeutic applications.
Used in Agricultural Chemistry:
In the field of agricultural chemistry, 2-Bromo-5,6-dimethoxy-3-nitropyridine is utilized for the synthesis of new pesticides. Its chemical properties enable the creation of innovative and effective pest control agents.
Used in Research and Development:
2-Bromo-5,6-dimethoxy-3-nitropyridine has been studied for its potential biological and pharmacological activities. Its diverse applications in different industries make it a valuable compound for research and development purposes, paving the way for new discoveries and advancements in various fields.

Upstream product

• 79491-46-6 2,6-dibromo-3-methoxy-5-nitropyridine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 6602-33-1 2,6-dibromopyridin-3-ol 
• 79491-45-5 2,6-dibromo-3-methoxylpyridine 
• 124-41-4 sodium methylate 
• 67-56-1 methanol 

Downstream Products

• 79491-49-9 3-amino-5,6-dimethoxypyridine 

Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS

Disclosed herein are compounds of Formula I'. Compounds of Formula I' inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase- dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

Phosphoinositide-3-kinase inhibitors: Evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511

Replacement of the piperazine sulfonamide portion of the PI3Kα inhibitor AMG 511 (1) with a range of aliphatic alcohols led to the identification of a truncated gem-dimethylbenzylic alcohol analog, 2-(5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)propan-2-ol (7). This compound possessed good in vitro efficacy and pharmacokinetic parameters and demonstrated an EC50 of 239 ng/mL in a mouse liver pharmacodynamic model measuring the inhibition of hepatocyte growth factor (HGF)-induced Akt Ser473 phosphorylation in CD1 nude mice 6 h post-oral dosing.

Thiophene-imidazopyridines

The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1

Synthetic Uses of the Sequential Ring Positional Reactivity in Pyridin-3-ol and Derivatives

A series of ring-substituted pyridin-3-ols has been prepared.The key to the scheme is the introduction of a bromo group to a specific ring position as a temporary blocking agent.As well as hydrogenolysis of the bromo function, nucleophilic displacement has also been investigated.