80676-35-3

Basic information

• Product Name: 4-(CHLOROMETHYL)DIBENZYL
• Synonyms: 4-(CHLOROMETHYL)DIBENZYL;1-(4-Chloromethylphenyl)-2-phenylethane;1-(Chloromethyl)-4-(2-phenylethyl)benzene;4-Chloromethylbibenzyl;1-(4-Chloromethyl)-2-phenylethane;1-(4-Chloromethylphenyl)-2-phenylethane,98%;1-Phenyl-2(4-chloromethyl)phenylethane
• CAS NO: 80676-35-3
• Molecular Formula: C₁₅H₁₅Cl
• Molecular Weight: 230.73
• Mol File: 80676-35-3.mol

Chemical Properties

• Melting Point: 37-38°C
• Boiling Point: 300.06°C (rough estimate)
• Flash Point: 144.1°C
• Appearance: /
• Density: 1.0980 (rough estimate)
• Vapor Pressure: 0.000473mmHg at 25°C
• Refractive Index: 1.6281 (estimate)
• CAS DataBase Reference: 4-(CHLOROMETHYL)DIBENZYL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(CHLOROMETHYL)DIBENZYL(80676-35-3)
• EPA Substance Registry System: 4-(CHLOROMETHYL)DIBENZYL(80676-35-3)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: 2811
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 80676-35-3(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C15H15Cl/c16-12-15-10-8-14(9-11-15)7-6-13-4-2-1-3-5-13/h1-5,8-11H,6-7,12H2

Upstream product

• 34224-29-8 (4-phenethylphenyl)methanol 
• 14518-67-3 methyl 4-(phenylethyl)benzoate 
• 32555-96-7 4-stilbenecarboxaldehyde 
• 101093-37-2 4-(methanol)stilbene 

Downstream Products

• 101282-93-3 bibenzyl-4-yl-acetonitrile 
• 1212-50-6 1-(4-formylphenyl)-2-phenylethane 
• 93022-35-6 (4-Phenethyl-benzylidenamino)-guanidin 
• 262863-92-3 4-hydroxy-1-(4-phenethylbenzyl)pyrrolidin-2-one 
• 1128268-04-1 Ethyl 1-[6-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate 
• 1146961-38-7 3-(6-hydroxy-1-methyl-3-{[4-(2-phenylethyl)benzyl]thio}-1H-indol-2-yl)-2,2-dimethylpropanoic acid 
• 1146961-41-2 2,2-dimethyl-3-(1-methyl-3-(methylthio)-6-{[4-(2-phenylethyl)-benzyl]oxy}-1H-indol-2-yl) propanoic acid 
• 934737-88-9 methyl 4-[(3E)-2-[2-(4-cyanophenyl)ethyl]-4-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)but-3-en-1-yl]benzoate 
• 1207618-28-7 ethyl 1-{4-[2-({[4-(2-phenylethyl)phenyl]methyl}oxy)phenyl]-1,3-thiazol-2-yl}-4-piperidinecarboxylate 
• 1240669-69-5 (2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)methanol 

Relevant articles and documents

Thiol compounds, their production and use

Compounds represented by general formula (1) or salts thereof which have a matrix metalloprotease inhibitory activity and are useful as drugs, wherein the rings A and B represent each an optionally substituted homocycle or heterocycle, etc.; R1s are the same or different and each represents hydrogen, optionally substituted hydrocarbyl, acyl, etc.; X1represents a bond, optionally substituted divalent aliphatic hydrocarbyl, etc.; X2represents a bond, optionally substituted divalent aliphatic hydrocarbyl, —O—, etc.; Ys are the same or different represents hydrogen, optionally substituted hydrocarbyl, oxo, etc.; m is 0 or 1; n is an integer of 1 to 3; q1is an integer of 1 to 2n+4; and q2is an integer of 0 to 2n+3, provided that q1+q2is 2n+4.

Modulation of pharmacological profile of diphenylethane (lefetamine- type) derivatives

With the aim to split the pharmacological properties of lefetamine (CAS 14148-99-3), some structural modifications of this compound have been studied. The basic group of lefetamine has been shifted from the alkyl chain to the vicinal phenyl ring and the N-substitution has been changed. The dimethylaminomethyl derivatives and chiefly the o-morpholinometyhl exhibited a strong anti-visceral chemical antinociception activity stripped of thermal antinociception properties and physical dependence liability. Furthermore through the introduction of a diethylaminomethyl group in the lefetamine structure some derivatives were selected exhibiting besided a significant increase in the anti-visceral chemical antinociception activity, remarkable local anesthetic properties.