34224-29-8

Basic information

• Product Name: Benzenemethanol, 4-(2-phenylethyl)-
• CAS NO: 34224-29-8
• Molecular Formula: C15H16O
• Molecular Weight: 212.291
• Mol File: 34224-29-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-(2-phenylethyl)-(34224-29-8)
• EPA Substance Registry System: Benzenemethanol, 4-(2-phenylethyl)-(34224-29-8)

Safety Data

• Hazardous Substances Data: 34224-29-8(Hazardous Substances Data)

Upstream product

• 32555-96-7 4-stilbenecarboxaldehyde 
• 538-39-6 1,2-di-p-tolylethane 
• 101093-37-2 trans-4-stilbenemethanol 
• 32555-96-7 4-styrylbenzaldehyde 
• 536-74-3 phenylacetylene 
• 42497-80-3 methyl 4-(phenylethynyl)benzoate 
• 785-79-5 4-phenethylbenzoic acid 
• 104-81-4 4-Methylbenzyl bromide 
• 104-87-0 4-methyl-benzaldehyde 
• 20498-63-9 1-(4-methylphenyl)-2-phenylethanol 
• 4714-21-0 4-methylstilbene 
• 14518-67-3 methyl 4-(phenylethyl)benzoate 
• 14310-20-4 4-methylbibenzyl 
• 101093-37-2 4-(methanol)stilbene 

Downstream Products

• 957204-73-8 1-(tert-butoxycarbonyl)-5-(4-phenethylbenzyloxy)indoline 
• 329773-33-3 methyl 4-(((5-methoxy-5-oxopentyl)(2-((4-phenethylbenzyl)oxy)phenethyl)amino)methyl)benzoate 
• 646995-35-9 4-[[(4-carboxybutyl)-[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride 
• 79757-91-8 1-(bromomethyl)-4-phenethylbenzene 
• 101282-93-3 bibenzyl-4-yl-acetonitrile 
• 80676-35-3 1-(chloromethyl)-4-(2-phenylethyl)benzene 

Relevant articles and documents

Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics

Recently, the structure of BAY 58-2667 bound to the Nostoc sp. H-NOX domain was published. On the basis of this structural information, we designed BAY 58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystallization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of αF helix containing 110-114 residues contributes to the higher activation triggered by 20.

Modulation of pharmacological profile of diphenylethane (lefetamine- type) derivatives

With the aim to split the pharmacological properties of lefetamine (CAS 14148-99-3), some structural modifications of this compound have been studied. The basic group of lefetamine has been shifted from the alkyl chain to the vicinal phenyl ring and the N-substitution has been changed. The dimethylaminomethyl derivatives and chiefly the o-morpholinometyhl exhibited a strong anti-visceral chemical antinociception activity stripped of thermal antinociception properties and physical dependence liability. Furthermore through the introduction of a diethylaminomethyl group in the lefetamine structure some derivatives were selected exhibiting besided a significant increase in the anti-visceral chemical antinociception activity, remarkable local anesthetic properties.