32555-96-7Relevant articles and documents
Synthesis and catalytic activities of 1-alkoxycarbonyl- and 1-carbamoylmethyl-5-phenyl-3-aryl-3H-imidazol-1-yliden-Pd(II) complexes
Koruk?u, Meliha ?etin,Co?kun, Necdet
, p. 47 - 56 (2017)
4-Phenyl-1-aryl-1H-imidazoles were reacted with α-haloesters and amides to give the corresponding imidazolium salts. The latter were used as starting materials for the synthesis of Pd(NHC) complexes. The catalytic activities of the newly prepared compounds were screened in a model coupling reaction. 1-Alkoxycarbonyl-5-phenyl-3-aryl-3H-imidazol-1-yliden-Pd(II) were shown to be better catalyst than the 1-carbamoylmethyl-5-phenyl-3-aryl-3H-imidazol-1-yliden-Pd(II) complexes. The catalysts were shown to be insensitive to the air oxygen and water.
Efficient and ligand free palladium catalyst for Suzuki and Heck cross-coupling reactions
Luo, Bin,Wang, Jiaqing,Ge, Danhua,Li, Xinming,Cao, Xueqin,Pan, Yue,Gu, Hongwei
, p. 1310 - 1314,5 (2014)
A simple and efficient system for Suzuki cross-coupling reactions was developed using a ligandless catalyst of Pd nanoclusters generated in situ from Pd(acac)2. The cross-coupling reactions proceeded under mild reaction conditions with a high reaction rate (5 min) to give various biaryls in high yields. The system also exhibited catalytic potential for Heck reaction between aryl bromides and styrene.
5-Nitrobenzimidazole containing Pd(II)catalyzed C[sbnd]C cross-coupling reactions: The effect of the N-substituent of the benzimidazole structure on catalyst activity
Buldurun, Kenan,?zdemir, ?smail
, p. 172 - 177 (2019)
A series of Pd(II)complexes (1a-e)were successfully synthesized by reaction of N-substituted 5-nitrobenzimidazole with [PdCl2(CNCH3)2]in toluene under argon reflux condition. Their catalytic activity in the Suzuki-Miyaura
Microwave-assisted synthesis of novel perimidinium salts as N-heterocyclic carbene precursors: Involvement in palladium-catalyzed cross-coupling reactions
Onar, Gulnihan,Karatas, Mert Olgun,Alici, Bülent,Cetinkaya, Engin
, p. 563 - 567 (2015)
[Figure not available: see fulltext.] In the current study, five novel perimidinium chlorides were synthesized in good yields by reaction of 1-(3-methylbenzyl)perimidine with five different alkyl chlorides under microwave irradiation in 30 minutes. Synthe
Synthesis and catalytic application of palladium complexes with picoline-functionalized benzimidazolin-2-ylidene ligands
Jahnke, Mareike C.,Pape, Tania,Hahn, F. Ekkehardt
, p. 1960 - 1969 (2009)
The picoline-functionalized benzimidazolium salts N-alkyl- N'-picolylbenzimidazolium bromide [alkyl = methyl (1), ethyl (2), n-propyl (3), n-butyl (4)] and the dipicoline-function-alized benzimidazolium bromide 5 have been synthesized. Reaction of the sal
Bimetallic nano alloy architecture on a special polymer: Ni or Cu merged with Pd for the promotion of the Mizoroki–Heck reaction and the Suzuki–Miyaura coupling
Patil, Vijay P,Kashid, Abhijit A,Solanki, Bhanupratap S,Kharul, Ulhas K,Iyer, Suresh
, (2021/02/12)
Abstract: Novel Ni-Pd and Cu-Pd bimetallic nano alloys was designed and heterogenized on the highly robust ABPBI [poly(2,5-benzimidazole)] polymer in high yields using NaBH4 as reducing agent. These were versatile ligand free catalysts for the Mizoroki–Heck reaction and Suzuki–Miyaura coupling. The bimetallic Ni-Pd-ABPBI catalyst for the Mizoroki–Heck reaction of 4-iodo anisole could be recycled 5 times with high yields. Aryl bromides could also be activated for the Mizoroki–Heck reaction using Cu-Pd-ABPBI NP catalysts, with moderate yields. Graphic abstract: Synopsis Novel bimetallic Ni-Pd and Cu-Pd nano alloys, heterogenized on the robust ABPBI [poly(2,5-benzimidazole)] polymer using NaBH4 as reducing agent, is described. These were versatile ligand free, noble metal conservative catalysts, for the Mizoroki–Heck reaction and the Suzuki–Miyaura coupling. Aryl bromides were activated for the Mizoroki–Heck reaction using the Cu-Pd-ABPBI catalyst.[Figure not available: see fulltext.]
Design, synthesis, and biological evaluation of pyrimidine analogs as SecA inhibitors
Bamba, Fante,Jin, Jinshan,Chaudhary, Arpana S.,Tai, Phang C.,Wang, Binghe
, p. 1334 - 1340 (2021/03/19)
SecA, a key component of the bacterial Sec-dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. We have previously reported pyrimidine analogs as SecA inhibitors. Herein, we report an extension of the earlier work in the synthesis and evaluation of a series of 15 5-cyanothiouracil derivatives as SecA inhibitors. All the compounds have been evaluated for their inhibition of SecA ATPase (EcSecAN68) and for their antimicrobial activity against Escherichia coli NR698 (a leaky mutant) and Bacillus anthracis Sterne. Twelve compounds showed IC50 of less than 6.3 μM when tested against EcSecAN68. In antimicrobial studies against E. coli NR698, six compounds showed MIC of 12.5 μM with three being less than 6.3 μM. Against B. anthracis Sterne, three compounds showed MIC of 6.3 μM.