808137-94-2

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
• Synonyms: Methyl 1H-pyrrolo[2,3-b]pyridine-3-carbo×ylate;Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate, 3-(Methoxycarbonyl)-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester;Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate;Methyl 7-azaindole-3-carboxylate;Methyl 7-azaindole-3-carb...
• CAS NO: 808137-94-2
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.18
• Product Categories: Heterocycle-Pyridine series
• Mol File: 808137-94-2.mol

Chemical Properties

• Melting Point: 57-59℃
• Appearance: /
• Density: 1.324
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.30±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester(808137-94-2)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester(808137-94-2)

Safety Data

• Hazardous Substances Data: 808137-94-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester is used as a key intermediate for the synthesis of various pharmaceuticals. Its heterocyclic structure allows for the development of novel chemical entities with potential therapeutic applications, contributing to the discovery of new drugs and treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester serves as a crucial building block for the synthesis of agrochemicals. Its properties enable the creation of new compounds with pesticidal or herbicidal activities, enhancing crop protection and yield.
Used in Medicinal Chemistry Research:
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester is utilized as a starting material in medicinal chemistry research. Its ability to form diverse chemical entities makes it a valuable tool for exploring new biological activities and potential drug candidates, advancing the field of drug development.

InChI:InChI=1/C9H8N2O2/c1-13-9(12)7-5-11-8-6(7)3-2-4-10-8/h2-5H,1H3,(H,10,11)

Upstream product

• 156270-06-3 7-azaindolyl-3-carboxylic acid 
• 67-56-1 methanol 
• 163220-69-7 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone 
• 245064-81-7 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 271-63-6 7-Azaindole 
• 13534-99-1 2-Amino-3-bromopyridine 
• 4414-89-5 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 310887-39-9 1H-pyrrolo[2,3-b]pyridine-3-carbohydrazide 

Relevant articles and documents

Synthetic method for 7-azaindole-3-methyl formate

The invention discloses a synthetic method for 7-azaindole-3-methyl formate, and belongs to the field of organic synthesis. The method comprises the steps of reacting 2-amino-3-bromopyridine as a reactant with 3-hydroxyl acrylonitrile metal salt in an acidic environment to synthesize 3-(3-bromopyridine-2-yl-amino) acrylonitrile; adding 3-(3-bromopyridine-2-yl-amino) acrylonitrile, alkali and a catalysis system to a solvent, and performing a reaction to generate 3-cyano-7-azaindole; and finally performing a reaction in the presence of methanol and hydrochloric acid to obtain 7-azaindole-3-methyl formate. According to the method, the raw materials are low in price and easy to obtain, the reaction steps are simple, the reaction conditions are mild, the product quality is stable, and the purity is high; and therefore, the method is suitable for industrial production.

Synthesis process of 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether

The invention relates to a synthesis process of 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether. The 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether is obtained by the following steps: adding 1H-pyrrolo[2,3-B] pyridine-3-carboxylic acid and methanol to a three-mouth flask; firstly heating the three-mouth flask at 35-58 DEG C for 10-25 minutes, and adding a mixture prepared from anhydrous calcium chloride and nano-aluminum oxide as a catalyst; carrying out heating reflux at 45-62 DEG C for 25-60 minutes, carrying out esterification reaction, cooling to a room temperature, filtering and evaporating excessive methanol from the filtrate at a temperature not higher than 65 DEG C at reduced pressure, so as to obtain the 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether. The adopted catalyst is convenient to operate when used, and is free of corrosivity or strong irritating smell, low in demands on hardware such as equipment, and beneficial to physical health of environmental personnel and operating personnel; the treatment after reaction is simple; the catalyst is low in price, available, low in cost and beneficial to large-scale application in industry.

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Desulfonylation of indoles and 7-azaindoles using sodium tert-butoxide

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PYRIDINONYL PDK1 INHIBITORS

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