1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester
• CAS No.: 808137-94-2
• Molecular Formula: C9H8 N2 O2
• Molecular Weight: 176.17
• Hs Code.: 2933990090
• Mol file: 808137-94-2.mol

Synonyms:Methyl1H-pyrrolo[2,3-b]pyridine-3-carboxylate

Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester

Chemical Property:

• Melting Point: 57-59℃
• Refractive Index: 1.648
• PKA: 12.30±0.40(Predicted)
• PSA: 54.98000
• Density: 1.324
• LogP: 1.34950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl1H-Pyrrolo[2,3-b]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester

There total 10 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (4414-89-5) → 1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester (808137-94-2)

Guidance literature:

With hydrogenchloride; In methanol; water; at 80 ℃; for 10h; Temperature;

Reference yield: 87.0%

methanol (67-56-1) + 7-azaindolyl-3-carboxylic acid (156270-06-3) → 1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester (808137-94-2)

Guidance literature:

methanol; 7-azaindolyl-3-carboxylic acid; at 36 ℃; for 0.25h;

With aluminium oxide nanoparticles; calcium chloride; at 50 ℃; for 0.75h; Temperature;

Reference yield: 85.0%

methanol (67-56-1) + 2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (163220-69-7) → 1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester (808137-94-2)

Guidance literature:

With triethylamine; at 20 ℃; for 2h;

upstream raw materials:

7-azaindolyl-3-carboxylic acid

diazomethyl-trimethyl-silane

methanol

2,2,2-trichloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

Downstream raw materials:

1H-pyrrolo[2,3-b]pyridine-3-carbohydrazide

Refernces

• 1、 -. "Synthesis process of 1H-pyrrolo[2,3-B] pyridine-3-carboxylic methyl ether". Paragraph 0017; 0018. . Retrieved 2017/01/09.
• 2、 Chaulet, Charlotte,Croix, Cécile,Basset, Joan,Pujol, Maria-Dolores,Viaud-Massuard, Marie-Claude. "Desulfonylation of indoles and 7-azaindoles using sodium tert-butoxide". experimental part. p. 1481 - 1484. Retrieved 2010/08/22.