825633-93-0

Basic information

• Product Name: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone
• Synonyms: 2-Benzyl-5-iodopyridazin-3(2H)-one;5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone;2-benzyl-5-iodopyridazin-3-one;2-Benzyl-5-iodopyridazin-3(2H)
• CAS NO: 825633-93-0
• Molecular Formula: C₁₁H₉IN₂O
• Molecular Weight: 312
• EINECS: -0
• Mol File: 825633-93-0.mol

Chemical Properties

• Melting Point: 136-137℃
• Boiling Point: 370℃
• Flash Point: 178℃
• Appearance: /
• Density: 1.70
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(825633-93-0)
• EPA Substance Registry System: 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone(825633-93-0)

Safety Data

• Hazardous Substances Data: 825633-93-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone is used as a reactant in high-temperature palladium (Pd)-catalyzed intramolecular direct arylations. This reaction is crucial for the synthesis of complex organic molecules, including pharmaceutical compounds, where the formation of carbon-carbon bonds is essential.
Used in Organic Synthesis:
5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone serves as a valuable building block in organic synthesis, enabling the construction of diverse molecular structures. Its unique functional groups and structural features make it suitable for various synthetic transformations, leading to the development of new compounds with potential applications in various industries.
Used in Chemical Research:
As a novel and interesting chemical entity, 5-Iodo-2-(phenylmethyl)-3(2H)-pyridazinone is employed in chemical research to explore new reaction pathways, investigate the reactivity of functional groups, and understand the underlying mechanisms of various chemical processes. This research can contribute to the advancement of synthetic methodologies and the discovery of new compounds with potential applications.

Upstream product

• 100-39-0 benzyl bromide 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 
• 41933-33-9 2-benzyl-4,5-dichloro-3(2H)-pyridazinone 

Downstream Products

• 825634-03-5 2-benzyl-5-vinylpyridazin-3(2H)-one 
• 825634-14-8 2-benzyl-5-[3-hydroxy-3-phenylprop-1-yn-1-yl]pyridazin-3(2H)-one 
• 1235545-41-1 2-benzyl-5-(4-fluorophenyl)pyridazin-3(2H)-one 
• 1041014-98-5 2-benzyl-5-{[2-bromo-4-(trifluoromethoxy)phenyl]amino}pyridazin-3(2H)-one 
• 1041015-02-4 2-benzyl-5-{[2-bromo-4-methylphenyl]amino}pyridazin-3(2H)-one 
• 1001620-00-3 C₁₆H₁₆N₂O₃ 
• 825634-08-0 methyl (2E)-3-(1-benzyl-6-oxo-1,6-dihydropyridazin-4-yl)acrylate 
• 1001620-01-4 C₂₀H₁₆N₂O₃ 
• 825633-94-1 5-iodo-2,3-dihydropyridazin-3-one 

Relevant articles and documents

NOVEL NITROGEN-CONTAINING AROMATIC HETEROCYCLIC COMPOUND

A compound represented by general formula [1] wherein X represents N or the like, Y represents CH or the like; RA represents a cycloalkyl group which may be substituted or the like, R1 represents an alkyl group or the like, R2 represents an alkyl group which may be substituted or the like, R3 represents a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has an inhibitory activity on aldosterone synthetase, and is useful as a prophylactic and/or therapeutic agent for various diseases or symptoms associated with aldosterone.

PYRIDAZINONE DERIVATIVES AS PHOSHOINOSITIDE 3-KINASES INHIBITORS

Compounds of formula (I) described herein inhibit phosphoinositide 3-kinases (PI3K) and useful for the treatment of disorders associated with PI3K enzymes.

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

IMIDAZO[1,2-a]PYRIDINES AND IMIDAZO[1,2-b]PYRIDAZINES AS MARK INHIBITORS

The invention encompasses imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives which selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease. Pharmaceutical compositions and methods of use are also included.

Pyridazine derivatives. Part 39: Reactivity of 5-iodopyridazin-3(2H)-ones in palladium-catalysed reactions

In the search for novel antiplatelet agents, convenient and efficient methods for the preparation of 2,5-disubstituted pyridazin-3(2H)-ones are reported that utilise palladium-catalysed cross-coupling reactions. A post-coupling base-promoted isomerisation