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828273-03-6

4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 828273-03-6 Structure

  • Basic information

    1. Product Name: 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE
    2. Synonyms: 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE;[4-(2,4-dichlorophenyl)pyrimidin-2-yl]amine;4-(2,4-dichlorophenyl)-2-pyrimidinamine;STK305204
    3. CAS NO:828273-03-6
    4. Molecular Formula: C10H7Cl2N3
    5. Molecular Weight: 240.08868
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 828273-03-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 432.3±53.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.434±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 2.68±0.10(Predicted)
    10. CAS DataBase Reference: 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE(828273-03-6)
    12. EPA Substance Registry System: 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE(828273-03-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 828273-03-6(Hazardous Substances Data)

828273-03-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 828273-03-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,8,2,7 and 3 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 828273-03:
(8*8)+(7*2)+(6*8)+(5*2)+(4*7)+(3*3)+(2*0)+(1*3)=176
176 % 10 = 6
So 828273-03-6 is a valid CAS Registry Number.

828273-03-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2,4-DICHLOROPHENYL)PYRIMIDIN-2-AMINE

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:828273-03-6 SDS

828273-03-6Downstream Products

828273-03-6Relevant articles and documents

Synthesis and biological evaluation of oxindole linked indolyl-pyrimidine derivatives as potential cytotoxic agents

Prajapti, Santosh Kumar,Nagarsenkar, Atulya,Guggilapu, Sravanthi Devi,Gupta, Keshav Kumar,Allakonda, Lingesh,Jeengar, Manish Kumar,Naidu,Babu, Bathini Nagendra

supporting information, p. 3024 - 3028 (2016/06/13)

In our endeavor towards the development of effective cytotoxic agents, a series of oxindole linked indolyl-pyrimidine derivatives were synthesized and characterized by IR, 1H NMR, 13C NMR and Mass spectral analysis. All the newly synthesized target compounds were assessed against PA-1 (ovarian), U-87MG (glioblastoma), LnCaP (prostate), and MCF-7 (Breast) cancer cell lines for their cytotoxic potential, with majority of them showing inhibitory activity at low micro-molar concentrations. Significantly, compound 8e was found to be most potent amongst all the tested compounds with an IC50 value of (2.43 ± 0.29 μM) on PA-1 cells. The influence of the most active cytotoxic compound 8e on the cell cycle distribution was assessed on the PA-1 cell line, exhibiting a cell cycle arrest at the G2/M phase. Moreover, acridine orange/ethidium bromide staining and annexin V binding assay confirmed that compound 8e can induce cell apoptosis in PA-1 cells. These preliminary results persuade further investigation on the synthesized compounds aiming to the development of potential cytotoxic agents.

Pyrimidine Derivatives As HSP90 Inhibitors

-

Page/Page column 45; 60, (2009/09/07)

The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR3; R1 is a monocyclic or bicyclic carbocyclic or

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