832735-58-7

Basic information

• Product Name: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one
• Synonyms: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one;4-Bromo-1-ethylpyridin-2(1H)-one
• CAS NO: 832735-58-7
• Molecular Formula: C₇H₈BrNO
• Molecular Weight: 202.06
• Mol File: 832735-58-7.mol

Chemical Properties

• Boiling Point: 272.0±33.0 °C(Predicted)
• Appearance: /
• Density: 1.547±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1?+-.0.70(Predicted)
• CAS DataBase Reference: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one(832735-58-7)
• EPA Substance Registry System: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one(832735-58-7)

Safety Data

• Hazardous Substances Data: 832735-58-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-bromo-1-ethyl-1,2-dihydropyridin-2-one is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
4-bromo-1-ethyl-1,2-dihydropyridin-2-one is utilized as an intermediate in the production of agrochemicals, where it plays a crucial role in the synthesis of pesticides and other agricultural chemicals to improve crop protection and yield.
Used in Research and Development:
4-bromo-1-ethyl-1,2-dihydropyridin-2-one is employed as a research compound for studying its antimicrobial and antitumor properties, which can lead to the discovery of novel treatments for infectious diseases and cancer.
Used in Chemical Synthesis:
Due to its unique structure containing a bromine atom and a pyridin-2-one ring, 4-bromo-1-ethyl-1,2-dihydropyridin-2-one serves as a versatile building block for the preparation of diverse chemical compounds with potential applications in various fields, including materials science, organic synthesis, and medicinal chemistry.

Upstream product

• 36953-37-4 4-bromo-2(1H)-pyridinone 
• 75-03-6 ethyl iodide 

Relevant articles and documents

HERBICIDAL PYRIDAZINUM BASED COMPOUNDS

Compounds of the formula (I), wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants

Despite the initial benefit demonstrated in clinical setting with ALK inhibitors, the challenging resistant mutants (F1174L, L1196M and G1202R) invariably developed. In this work, a series of 2-aminopyridine derivatives were designed and synthesized by C-5 position incorporation of a 2-pyridone moiety and bioisosteric replacement of the C-3 position linkers. Optimization of the 2-aminopyridine derivatives led to the identification of hit 18d displaying a significant growth inhibition against a variety of ALK-addicted cancer cells. Especially in the case of ALK-positive Karpas-299 cell, 18d exhibited excellent anti-proliferative potency with an IC50 value of about 40 nM. Moreover, 18d demonstrated encouraging activities against wild-type ALK (19 nM), ROS1 (2.3 nM) as well as challenging crizotinib-resistant ALKL1196M and ALKG1202R mutants with IC50 values of 45 nM and 22 nM, respectively. Additionally flow cytometric analysis indicates that 18d inhibited Karpas-299 cell viability via G1 phase arrest. Taken together, this work provided a promising ALK inhibitor to circumvent the clinical crizotinib-resistant mutants.

Condensed derivatives of imidazole useful as pharmaceuticals

The invention relates to the compounds (I) and their acids and bases salts: wherein: the dotted line indicates a double bond; X is N or C-R1 and Y is N or C-R2, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is Hydrogen or a substituent as defined in the application, or B is a (4-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, and possibly substituted as defined in the application; B not being Hydrogen when X is N and Y is C-R2; R1 is Hydrogen or a substituent as defined in the application; B and R1 cannot be simultaneously Hydrogen; R2 is Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.