4-bromo-1-ethyl-1,2-dihydropyridin-2-one

Base Information

• Chemical Name: 4-bromo-1-ethyl-1,2-dihydropyridin-2-one
• CAS No.: 832735-58-7
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Mol file: 832735-58-7.mol

Synonyms:

Chemical Property of 4-bromo-1-ethyl-1,2-dihydropyridin-2-one

Chemical Property:

• Boiling Point: 272.0±33.0 °C(Predicted)
• PKA: -1?+-.0.70(Predicted)
• PSA: 22.00000
• Density: 1.547±0.06 g/cm3(Predicted)
• LogP: 1.63070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-1-ethylpyridin-2(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-1-ethyl-1,2-dihydropyridin-2-one

There total 2 articles about 4-bromo-1-ethyl-1,2-dihydropyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-bromo-2(1H)-pyridinone (36953-37-4) + ethyl iodide (75-03-6) → 4-bromo-1-ethyl-1,2-dihydropyridin-2-one (832735-58-7)

Guidance literature:

4-bromo-2(1H)-pyridinone; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.5h;

ethyl iodide; In tetrahydrofuran; mineral oil; at 20 - 50 ℃; for 40h;

Reference yield: 81.0%

4-bromo-2(1H)-pyridinone (36953-37-4) → 4-bromo-1-ethyl-1,2-dihydropyridin-2-one (832735-58-7)

Guidance literature:

4-bromo-2(1H)-pyridinone; With sodium hydride; In tetrahydrofuran; for 0.25h; Cooling with ice;

ethyl halide; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1016/j.ejmech.2019.111734

Reference yield:

3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine (877399-49-0) + 4-bromo-1-ethyl-1,2-dihydropyridin-2-one (832735-58-7) → (R)-6-amino-1'-ethyl-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-[3,4'-bipyridine]-2'(1'H)-one

Guidance literature:

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 10h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.111734

upstream raw materials:

4-bromo-2(1H)-pyridinone

ethyl iodide

Refernces

• 1、 Chen, Wenteng,Guo, Xiao,Zhang, Can,Ke, Di,Zhang, Guolin,Yu, Yongping. "Discovery of 2-aminopyridines bearing a pyridone moiety as potent ALK inhibitors to overcome the crizotinib-resistant mutants". . . Retrieved 2019/10/02.