848360-85-0

Basic information

• Product Name: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene
• Synonyms: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene
• CAS NO: 848360-85-0
• Molecular Formula: C₈H₆BrF₃O₂
• Molecular Weight: 271.0312496
• Product Categories: alkyl bromide
• Mol File: 848360-85-0.mol

Chemical Properties

• Boiling Point: 218.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.594±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene(848360-85-0)
• EPA Substance Registry System: 1-broMo-2-Methoxy-4-(trifluoroMethoxy)benzene(848360-85-0)

Safety Data

• Hazardous Substances Data: 848360-85-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-2-Methoxy-4-(trifluoromethoxy)benzene is used as a medication for the prevention of migraine headaches in adults. It functions by inhibiting the activity of calcitonin gene-related peptide (CGRP), a neuropeptide that plays a crucial role in the transmission of pain signals. By blocking CGRP activity, this compound helps to reduce the frequency and severity of migraines, providing relief to patients suffering from this condition.
As a medication, Galcanezumab is available in the form of a solution for injection under the brand name Emgality. It has been approved for use in various countries around the world, offering a valuable treatment option for adults experiencing migraines. The development and application of this compound demonstrate the importance of organic chemistry in creating effective pharmaceuticals to address specific health concerns.

Upstream product

• 205371-26-2 2-bromo-5-(trifluoromethyloxy)phenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 827-99-6 3-(trifluoromethoxy)phenol 

Downstream Products

• 355836-10-1 2-methoxy-4-trifluoromethoxybenzeneboronic acid 
• 848947-91-1 2-methoxy-4-(trifluoromethoxy)-benzoic acid 
• 848361-08-0 C₂₁H₂₅BrF₃N₃O₂ 

Relevant articles and documents

Selective sodium channel regulator as well as preparation and application thereof

The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.

Selective sodium channel regulator as well as preparation and application thereof

The invention provides a compound serving as a selective sodium channel regulator and a synthesis and use method, and particularly provides a compound shown as a formula (I), a preparation method of the compound and application of the compound serving as the selective sodium channel regulator. The compounds exhibit excellent activity as a regulator of sodium channels.

Selective sodium channel regulator, preparation and application thereof

The invention provides a compound as a selective sodium channel regulator, a synthesis method and a use method thereof, and particularly provides a compound as shown in a formula (I), a preparation method of the compound and application of the compound as the selective sodium channel regulator. The compounds exhibit excellent activity as sodium channel modulators.

ESTERS AND CARBAMATES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS

Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS

Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxi

5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds

5-aryl-Pyrazolo[4,3-d]pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a n