849937-91-3 Usage
Uses
Used in Pharmaceutical Industry:
4,6-Difluoronicotinic acid is used as a pharmaceutical intermediate for the production of other drugs. Its unique structure and properties make it a valuable component in the synthesis of various pharmaceutical compounds.
Used in Organic Chemistry Research:
4,6-Difluoronicotinic acid is used as a research compound in organic chemistry, allowing scientists to explore its reactivity, stability, and potential applications in the development of new chemical entities and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 849937-91-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,9,3 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 849937-91:
(8*8)+(7*4)+(6*9)+(5*9)+(4*3)+(3*7)+(2*9)+(1*1)=243
243 % 10 = 3
So 849937-91-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H3F2NO2/c7-4-1-5(8)9-2-3(4)6(10)11/h1-2H,(H,10,11)
849937-91-3Relevant articles and documents
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick
Schlosser, Manfred,Bobbio, Carla,Rausis, Thierry
, p. 2494 - 2502 (2007/10/03)
(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.
