85068-36-6

Basic information

• Product Name: 2,5-DIFLUOROBENZOPHENONE
• Synonyms: Methanone, (2,5-difluorophenyl)phenyl-;2,5-DIFLUOROBENZOPHENONE;(2,5-DIFLUORO-PHENYL)-PHENYL-METHANONE;2,5-Difluorobenzophenone, 97+%;2,5-Difluorobenzophenone 97%;(2,5-Difluorophenyl)phenyl ketone
• CAS NO: 85068-36-6
• Molecular Formula: C₁₃H₈F₂O
• Molecular Weight: 218.2
• EINECS: 285-298-2
• Product Categories: Miscellaneous;Fluorine series
• Mol File: 85068-36-6.mol

Chemical Properties

• Boiling Point: 120 °C
• Flash Point: >110°C
• Appearance: /
• Density: 1.262
• Vapor Pressure: 0.000109mmHg at 25°C
• Refractive Index: 1.5693
• BRN: 4417185
• CAS DataBase Reference: 2,5-DIFLUOROBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)
• EPA Substance Registry System: 2,5-DIFLUOROBENZOPHENONE(85068-36-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 85068-36-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Difluorobenzophenone is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that contribute to the development of new drugs.
Used in Perfume Industry:
2,5-Difluorobenzophenone is used as a building block in the creation of perfumes, leveraging its chemical structure to produce distinct and desirable fragrances.
Used in Industrial Applications:
2,5-Difluorobenzophenone is used as a photoinitiator in UV-curing applications, facilitating the curing process of various materials under ultraviolet light.
Used in Specialty Chemicals and Polymers Manufacturing:
2,5-Difluorobenzophenone is used as a key ingredient in the production of specialty chemicals and polymers, owing to its unique properties that enhance the performance of these materials.
Health Hazard Classification:
2,5-Difluorobenzophenone is classified as a low to moderate health hazard with mild skin and eye irritation potential, indicating the need for proper handling and safety measures during its use in various applications.

InChI:InChI=1/C13H8F2O/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H

Upstream product

• 540-36-3 para-difluorobenzene 
• 98-88-4 benzoyl chloride 
• 119-61-9 benzophenone 
• 108-86-1 bromobenzene 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 98-80-6 phenylboronic acid 
• 201230-82-2 carbon monoxide 
• 211512-93-5 Trifluoro-methanesulfonic acid 2,5-difluoro-phenyl ester 
• 63468-90-6 phenylglyoxylic acid potassium salt 
• 64248-64-2 2,5-difluorobenzonitrile 
• 80-17-1 benzenesufonyl hydrazide 
• 408492-25-1 2-(2,5-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 100-52-7 benzaldehyde 

Downstream Products

• 7112-00-7 2,4-dimethyl-5-phenyl-3H-1,2,4-triazole-3-thione 
• 342-59-6 5-fluoro-2-methoxybenzophenone 
• 100994-58-9 2,5-difluorobenzophenone 2,4-dimethylthiosemicarbazone 
• 100994-59-0 5-(2,5-difluorophenyl)-2,4-dimethyl-5-phenyl-1,2,4-triazolidine-3-thione 
• 57614-63-8 5-Fluoro-3-phenyl-1H-indazole 
• 88499-59-6 N₂-<(2,5-difluorophenyl)phenylmethylene>-N-methylhydrazinecarbothioamide 
• 300350-05-4 4-fluoro-2-benzoylthiophenol 
• 1227300-72-2 C₂₁H₁₂FN 
• 1220532-00-2 C₁₇H₁₂FNO₃ 
• 1421364-33-1 (2,5-difluorophenyl)diphenylmethanol 
• 119-61-9 benzophenone 
• 1204771-72-1 C₁₇H₁₀FN₃O₂S 
• 1569280-41-6 C₁₉H₁₄FN₃O₂S 
• 1606178-15-7 (5-fluoro-2-(furan-2-yl)phenyl)(phenyl)methanone 

Relevant articles and documents

Photo-induced oxidative cleavage of C-C double bonds of olefins in water

The carbonyl compounds, synthesized by the oxidative cleavage of their corresponding olefins, are of great significance in organic synthesis, especially aryl ketones. We have developed a gentle and effective protocol, using acid red 94 as the organic metal-free photocatalyst, O2 as the oxidant, and water as the solvent. Under visible light irradiation, aryl ketone derivatives were obtained in moderate to excellent yields, showing good economic and environmental advantages.

Transition Metal Catalyst-Free, Base-Promoted 1,2-Additions of Polyfluorophenylboronates to Aldehydes and Ketones

A novel protocol for the transition metal-free 1,2-addition of polyfluoroaryl boronate esters to aldehydes and ketones is reported, which provides secondary alcohols, tertiary alcohols, and ketones. Control experiments and DFT calculations indicate that both the ortho-F substituents on the polyfluorophenyl boronates and the counterion K+ in the carbonate base are critical. The distinguishing features of this procedure include the employment of commercially available starting materials and the broad scope of the reaction with a wide variety of carbonyl compounds giving moderate to excellent yields. Intriguing structural features involving O?H???O and O?H???N hydrogen bonding, as well as arene-perfluoroarene interactions, in this series of racemic polyfluoroaryl carbinols have also been addressed.

Preparation method of aromatic ketone

The invention discloses a preparation method of aromatic ketone. Under the effects of a palladium catalyst and a nitrogen-containing ligand, nitrile compounds and arylsulfonylhydrazide take desulfurization addition reaction in an organic solvent; after the reaction is completed, post treatment is performed to obtain aromatic ketone. The reaction is applicable to aromatic nitrile compounds, and isalso applicable to aliphatic nitrile compounds; the reaction realizes the wide substrate applicability and functional group tolerance; the potential application value is realized in the aspect of aryl-carbonyl building.

Method for preparing aromatic ketone in aqueous phase

The invention discloses a method for preparing aromatic ketone in an aqueous phase, comprising the following steps: enabling aryl formyl potassium formate and aryl potassium fluoborate to generate decarboxylation acylation reaction in water under the actions of a silver catalyst and an oxidizing agent, and performing treatment after reaction is ended to obtain the disclosed aromatic ketone. According to the preparation method, the silver catalyst replaces a noble metal catalyst, water is taken as a solvent, an aromatic ketone product is obtained with relatively high yield, the adopted catalystis low in cost and easy to obtain, reaction conditions are mild, and meanwhile, the product is good in university, and therefore, the method has good application potential.

Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides with nitriles has been successfully achieved under mild conditions. This transformation is a new method for the addition reaction to nitriles with arylsulfonyl hydrazides as arylating agent, thus providing an alternative synthesis of aryl ketones. The reported addition reaction is tolerant to many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents. Notably, the reported denitrogenative and desulfinative addition was also appropriate for alkyl nitriles, making this newly developed transformation attractive.

Ag(i)/persulfate-catalyzed decarboxylative coupling of α-oxocarboxylates with organotrifluoroborates in water under room temperature

The decarboxylative coupling reaction of α-oxocarboxylates and organotrifluoroborates was carried out smoothly in the presence of catalytic AgNO3 using K2S2O8 as oxidant to generate diarylketone products in high

Carbonylative coupling of aryl tosylates/triflates with arylboronic acids under CO atmosphere

The carbonylative Suzuki-Miyaura reaction between aryl tosylates/triflates with arylboronic acid is herein reported, using base-free conditions and a balloon pressure of carbon monoxide. Under these conditions, unsymmetrical biaryl ketones were obtained in modest to excellent yields. This method was adapted to the synthesis of oxybenzone and ketoprofen in good yields under mild conditions.

Silver-catalyzed decarboxylative acylation of arylglyoxylic acids with arylboronic acids

The silver-catalyzed coupling of arylboronic acids with arylglyoxylic acids was found to be an extremely efficient route for the synthesis of unsymmetrical diaryl ketones. It can be conducted on a gram scale under mild and open-flask conditions with good functional group compatibility, avoiding the addition of expensive and/or toxic metals. This journal is

Steric and electronic effects influencing β-aryl elimination in the Pd-catalyzed carbon-carbon single bond activation of triarylmethanols

An analysis of the palladium-catalyzed activation of carbon-carbon single bonds within triarylmethanols has led to a greater understanding of factors influencing the β-aryl elimination process responsible for C-C bond cleavage. A series of competition reactions were utilized to determine that β-aryl elimination of aryl substituents containing ortho-substitution proceeds with significant preference to unsubstituted phenyl rings. Further experiments indicate that substrates containing either strongly donating or withdrawing substituents are cleaved from triarylmethanols more readily than relatively neutral species.

Selective electrochemical aromatic fluorination of acetophenone and benzophenone

Electrochemical fluorination of acetofenone and benzophenone was studied in anhydrous HF and in solutions. The electrochemical fluorination of acetophenone in HF occurred exclusively in the ring and furnished ortho- and meta-isomers of fluoroacetophenone,