851000-71-0

Basic information

• Product Name: 1-BOC-3-PHENYL-3-HYDROXYPYRROLIDINE
• Synonyms: 1-BOC-3-PHENYL-3-HYDROXYPYRROLIDINE
• CAS NO: 851000-71-0
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.335
• Mol File: 851000-71-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-BOC-3-PHENYL-3-HYDROXYPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-3-PHENYL-3-HYDROXYPYRROLIDINE(851000-71-0)
• EPA Substance Registry System: 1-BOC-3-PHENYL-3-HYDROXYPYRROLIDINE(851000-71-0)

Safety Data

• Hazardous Substances Data: 851000-71-0(Hazardous Substances Data)

Usage

Structure

A pyrrolidine ring with a hydroxyl group and a phenyl group substituted at the third position

BOC Group

A protecting group used in organic synthesis to temporarily mask reactive functional groups

Applications

Potential use in organic synthesis and pharmaceutical research, particularly in the development of drug molecules

Safety

Important to handle with care, following proper safety procedures and guidelines for handling and disposal

Upstream product

• 108-86-1 bromobenzene 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 1616295-80-7 4-phenyl-2,3-dihydro-1H-pyrrole 
• 1616295-81-8 tert-butyl 3-fluoro-3-phenylpyrrolidine-1-carboxylate 
• 256950-61-5 tert-butyl 3-phenyl-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1547068-02-9 3-fluoro-3-phenylpyrrolidine 
• 1616294-29-1 2-cyclopropyl-4-(3-fluoro-3-phenyl-pyrrolidin-1-yl)-6,7-dimethoxy-quinazoline 
• 1488-02-4 3-phenylpyrrolidin-3-ol hydrochloride 
• 49798-31-4 3-phenyl-3-pyrrolidinol 
• 52906-59-9 3-phenyl-3-pyrroline 

Relevant articles and documents

COMPOUNDS AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR

The present invention provides compounds of Formula (I) shown above and their pharmaceutically acceptable salt, solvates, isomers, or prodrugs, as well as pharmaceutical compositions containing these compounds. Also provided by the invention is a method for treating a disorder mediated by macrophage migration inhibitory factor in a subject, comprising administering to the subject in need thereof a compound or a pharmaceutical composition of this invention.

Copper-catalyzed intramolecular redox reaction: Asymmetric synthesis of chiral 2-(1H-pyrrol-1-yl)-mandelic acid esters

An efficient approach to chiral α-hydroxy acid esters by Lewis acid-mediated asymmetric [1,5]-hydride shift and isomerization of 2-(3-pyrroline-1-yl)arylketone acid ester has been achieved in up to 96% yield and 94% ee. This protocol would be applied in the synthesis of chiral α-hydroxy acid derivatives with simplicity and high enantioselectivity.

DOPAMINE D2 RECEPTOR LIGANDS

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Intramolecular redox reaction for the synthesis of N-aryl pyrroles catalyzed by Lewis acids

An efficient approach to synthesize N-aryl pyrroles via Lewis acid-mediated 1,5-hydride shift and isomerization of 2-(3-pyrroline-1-yl)arylaldehydes has been achieved in up to 89% yield. This methodology is applicable to the synthesis of fluorazene deriva

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CHIRAL AUXILIARIES

Chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity, and compounds represented by the following the general formula (I) or the general formula (XI) for introducing the chiral auxiliaries.