85404-48-4

Basic information

• Product Name: (-)-Haplomyrfolin
• Synonyms: (-)-Haplomyrfolin
• CAS NO: 85404-48-4
• Molecular Formula: C₂₀H₂₀O₆
• Molecular Weight: 356.3692
• Mol File: 85404-48-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-Haplomyrfolin(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-Haplomyrfolin(85404-48-4)
• EPA Substance Registry System: (-)-Haplomyrfolin(85404-48-4)

Safety Data

• Hazardous Substances Data: 85404-48-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(-)-Haplomyrfolin is used as a potential drug candidate for the treatment of cancer due to its strong antitumor properties. It has shown promise in targeting and inhibiting the growth of cancer cells, making it a valuable asset in the development of new cancer therapies.
Used in Anti-inflammatory Applications:
(-)-Haplomyrfolin is used as an anti-inflammatory agent for the treatment of various inflammatory diseases. Its strong anti-inflammatory properties can help alleviate symptoms and reduce the severity of inflammation in affected individuals.
Used in Antifungal Applications:
(-)-Haplomyrfolin is used as an antifungal agent against a variety of pathogenic fungi. Its significant antifungal activity makes it a potential candidate for the development of new antifungal drugs to combat fungal infections.
Used in Drug Development Research:
(-)-Haplomyrfolin is used as a subject of research in drug development, where its unique tricyclic structure and biological activities are studied to understand its mechanisms of action and potential applications in the treatment of various diseases.

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Relevant articles and documents

Modular synthesis and biological investigation of 5-hydroxymethyl dibenzyl butyrolactones and related lignans

Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselectively prepare a key intermediate. The reported synthetic route enables the modification of these lignans to give rise to 5-hydroxymethyl derivatives of these lignans. The biological activities of these analogues were assessed, with derivatives showing an excellent cytotoxic profile which resulted in programmed cell death of Jurkat T-leukemia cells with less than 2% of the incubated cells entering a necrotic cell death pathway.