cas 86483-43-4, 4,5-DICHLORO-2-(3,5-DICHLOROPHENYL)-2,3-DIHYDROPYRIDAZIN-3-ONE | Articles data ｜lookchem

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86483-43-4

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The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors
A structure-activity relationship study of the lead 5-[4-(benzylsulfonyl) piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one 1 has resulted in the identification of 2-(3,5-difluorophenyl)-4-(3-fluorocyclopentyloxy)-5-[4- (isopropylsulfonyl)piperazin-1-yl]-pyridazin-3(2H)-one 11c as a β-1,3-glucan synthase inhibitor. Compound 11c exhibited significant efficacy in an in vivo mouse model of Candida glabrata infection.
Ting, Pauline C.,Kuang, Rongze,Wu, Heping,Aslanian, Robert G.,Cao, Jianhua,Kim, David W.,Lee, Joe F.,Schwerdt, John,Zhou, Gang,Wainhaus, Samuel,Black, Todd A.,Cacciapuoti, Anthony,McNicholas, Paul M.,Xu, Yiming,Walker, Scott S.
scheme or table
p. 1819 - 1822
(2011/05/05)

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors
Methicillin resistant Staphylococcus aureus (MRSA) is a major health problem that has created a pressing need for new antibiotics. Compounds that inhibit the S. aureus SrtA sortase may function as potent anti-infective agents as this enzyme attaches virulence factors to the cell wall. Using high-throughput screening, we have identified several compounds that inhibit the enzymatic activity of the SrtA. A structure-activity relationship (SAR) analysis led to the identification of several pyridazinone and pyrazolethione analogs that inhibit SrtA with IC50 values in the sub-micromolar range. Many of these molecules also inhibit the sortase enzyme from Bacillus anthracis suggesting that they may be generalized sortase inhibitors.
Suree, Nuttee,Yi, Sung Wook,Thieu, William,Marohn, Melanie,Damoiseaux, Robert,Chan, Albert,Jung, Michael E.,Clubb, Robert T.
experimental part
p. 7174 - 7185
(2010/03/30)

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Chemical Properties

Boiling Point: 396.1°C at 760 mmHg
Flash Point:193.3°C
Density: 1.66g/cm³
Vapor Pressure: 1.75E-06mmHg at 25°C
Refractive Index: 1.67
PSA: 34.89000
LogP: 3.84610

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