- Unusual Reactivity of Silicon Grease Towards Metal Alkoxides: Serendipity for Structural Chemistry
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Controlled synthesis of moisture sensitive metal alkoxides demands the use of silicon grease for the inert synthetic manipulation of starting materials using glass apparatus to avoid adventitious hydrolysis. Spontaneous reaction of the siloxane units (?OSi(Me3)2)n) with the synthesized alkoxides often leads to molecular metal alkoxides based siloxane frameworks. These spontaneous incorporation of siloxane units into homo- and heterometallic alkoxide building blocks lead to the new multinuclear homo- and heterometallic alkoxide-siloxide compounds [Ce2(OtBu)4{Me2Si(OtBu)O}2(NO3)2] (1), [Zr{(OiPr)2{Me2SiO2}Sr{Zr2(OiPr)8}}2] (2) and [Sn2In2O2{Me2Si(OiPr)O}(OiPr)5]2 (3). Multifunctional coordination properties of these siloxane units enable the molecular approach to synthetically demanding polymetallic complexes for potential MOx-SiOx nanocomposites fabrication.
- Nahrstedt, Vanessa,Raauf, Aida,Hegemann, Corinna,Brune, Veronika,Schl?fer, Johannes,Mathur, Sanjay
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Read Online
- Synthesis and photochromic properties of new naphthopyrans
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[Figure not available: see fulltext.] Two novel isomeric naphthopyrans substituted with phenyl (13-butyl-6,7-dimethoxy-3,3-bis(6-methoxybiphenyl-3-yl)-3,13-dihydrobenzo[h]indeno[2,1-f]chromen-13-ol) and 4-(naphthalen-1-yl)phenyl (13-butyl-6,7-dimethoxy-3,3-bis[6-methoxy-4'-(naphthalenyl)-biphenyl-3-yl]-3,13-dihydrobenzo[h]indeno[2,1-f]chromen-13-ol) moieties were synthesized. Their photochromism, electrochemical and fluorescent properties were investigated. They displayed faster color fading rate and larger fluorescence quantum yield than 13-butyl-6,7-dimethoxy-3,3-bis(4-methoxyphenyl)-3,13-dihydrobenzo[h]indeno[2,1-f]chromen-13-ol. Moreover, they showed excellent photochromic and fluorescent properties both in solution and in polymethylmethacrylate film. In addition, cyclic voltammetry tests showed that the aromatic substituents had a significant effect on the electrochemical behavior of the naphthopyran derivatives.
- Zhao, Qian,Yang, Yanhua,Duan, Yingxiang,Tao, Xian,Shen, YingZhong
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p. 840 - 847
(2018/11/10)
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- Efficient Synthesis of N-Substituted 2,4-Azepandione Ring System as an Active Intermediate for Heterocyclic Syntheses
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An improved efficient synthesis for 2,4-azepandiones (3, 8, and 14) could be achieved by a careful control of the reaction conditions to cyclize ethyl 4-(N-acetylarylamino) butanoate (1, 7, and 13), respectively. The ethyl 4-arylamino butanoate (9 or 12) was prepared by stirring the ethyl 4-bromobutanoate and substituted anilines at room temperature. Then, they were acetylated with acetyl chloride and triethylamine under the conditions that avoid the formation of 2-pyrrolidinone derivatives 10. Due to the rapid decomposition of the acetylated product (7 or 13) to its starting material (9 or 12), the reaction mixture is directly transferred without workup to the next cyclization step. The azepandione synthesis is favored by using a weak base at low temperature, where it is in a competition with the other modes of ring closure. The structures of the new compounds were supported by correct analytical and spectral data.
- Waly, Mohamed A.,Yossif, Shiam A.,Ibrahim, Ismail T.,Sofan, Mamdouh A.
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p. 1318 - 1326
(2017/03/27)
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- Apparatus for producing of potassium tert -butoxide
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The utility model relates to an apparatus for producing of potassium tert -butoxide, including: reation kettle (1), reation kettle (1) loop through delivery pump (2), heater (3) are connected with pervaporation membrane separation unit (4), the export of holding back the side of pervaporation membrane separation unit (4) is connected with reation kettle (1), the infiltration side of pervaporation membrane separation unit (4) is provided with vacuum pump (5) and penetrant condenser (6), and (6) exit of penetrant condenser still is connected with infiltration fluid reservoir (7) and infiltration liquid pump (8). The utility model discloses process is simple, and conversion is rateed highly, and factor of safety is high, does not introduce the third component, and operating power consumption is low, and energy utilization is high.
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Paragraph 0028; 0029
(2017/07/01)
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- Preparation method for low residual granular sodium alkoxide or potassium alcoholate
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The invention provides a preparation method for low residual granular sodium alkoxide or potassium alcoholate. The method includes using sodium or potassium and alcohol as raw materials, mixing the mixture with a solvent, reacting in inert gas atmosphere by using a microwave heating method, and removing the residual alcohol and solvent in the presence of microwave after the reaction to get the granular sodium alkoxide or potassium alcoholate. The microwave frequency is 2450 +/- 50 MHz. The method can prepare sodium alkoxide or potassium alcoholate with low residual solvent, and the prepared sodium alkoxide or potassium alcoholate is large granular solid, so that the development from powdered product to granular product can be realized, and the problems of residual solvent and potential risk troubled human for a long time can be overcome.
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Paragraph 0039-0040
(2017/01/17)
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- Method and device for producing potassium tert-butoxide
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The invention relates to a device and technology for producing potassium tert-butoxide. The technology includes the following specific steps that 1, tertiary butanol and potassium hydroxide are reacted in a reaction kettle, and the liquid-phase reactant is fed into a pervaporation membrane for dehydration; 2, the material obtained through dehydration is returned into the reaction kettle to continue to participate in reacting. According to the device and technology, the process is simple, the reaction conversion ratio is high, the safety coefficient is high, third components are avoided, running energy consumption is low, and the energy utilization ratio is high.
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Paragraph 0026
(2017/06/02)
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- Structurally Simple Benzyl-Type Photolabile Protecting Groups for Direct Release of Alcohols and Carboxylic Acids
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Structurally simple benzyl-type photolabile protecting groups (PPGs) have been developed to release alcohols and carboxylic acids. Release of two substrates from one PPG chromophore has also been accomplished. (Chemical Equation Presented).
- Wang, Pengfei,Lu, Wenya,Devalankar, Dattatray A.,Ding, Zhenying
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p. 2114 - 2117
(2015/05/13)
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- Phosphorescent OLED and hole transporting materials for phosphorescent OLEDs
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The present invention relates to phosphorescent organic light-emitting diodes (OLEDs) comprising a hole-transporting or a hole-transporting and an electron-blocking layer comprising an N,N,N',N'-tetraaryl-phenylene-3,5-diamine or an N,N,N',N'-tetraaryl-1,1'-biphenyl-3,3'-diamine matrix compound and to new N,N,N',N'-tetraarylsubstituted m-arylene diamine compounds useful as hole-transporting and electron-blocking layer matrices in phosphorescent OLEDs.
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Page/Page column
(2014/05/07)
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- Novel antimalarial 3-azabicyclo[3.2.2]nonane derivatives
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The present invention relates to novel 3-azabicyclo[3.2.2]nonane derivatives of the general formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined in the specification. The novel 3-azabicyclo[3.2.2]nonane derivatives are particularly useful for treatment and prevention of malaria and trypanosomiasis.
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- SPIRO COMPOUNDS USEFUL AS ANTAGONISTS OF THE H1 RECEPTOR
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The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders.
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Page/Page column 32
(2009/03/07)
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- COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY
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ThThis invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap junction disorders.
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Page/Page column 16
(2008/06/13)
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- Process for the catalytic preparation of alkali metal alkoxides
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Alkali metal alkoxides are prepared by reacting alkali metal amalgam with alcohol in the presence of a catalyst comprising porous iron.
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Page/Page column 4
(2008/06/13)
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- Aryloxyheteroarylpropylamines, their preparation and use
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The present invention relates to aryloxyheteroarylpropylamines of formula I wherein, X is 2- or 3-thienyl-, furanyl or pyrrolyl, all of which are unsubstituted or optionally substituted; and, R is 3,4-methylenedioxyphenyl, aryl or heteroaryl, all of which are unsubstituted or optionally substituted; and, R1 and R2 are hydrocarbyl substituents, containing 1 to 11 carbon atoms, all of which are unsubstituted or optionally substituted; or hydrogen; or, R1 and R2 together form a 5, 6 or 7 membered ring containing at least one nitrogen atom, or optionally contains two nitrogen atoms, one or two oxygen atom(s) or one or two sulfur atom(s) or a combination thereof, which ring is unsubstituted or optionally substituted,a method of preparing the same and to pharmaceutical compositions comprising the compounds., The compounds of the invention have activity against calcium overload in brain cells, and are useful in the treatment of anoxia, traumatic injury, ischemia, migraine, epilepsy, Parkinson's disease, Alzheimer's disease and other neurodegenerative diseases.
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- Pesticides
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Compounds of the formula STR1 wherein: R1 is phenyl or phenyl mono- to tri-substituted by R4 ; R2 is hydrogen, C1 -C5 alkyl, C1 -C5 alkyl substituted by the radical OR5 or by the radical SR5, C3 -C6 cycloalkyl, C3 -C6 cycloalkyl mono- to tri-substituted by C1 -C4 alkyl or by halogen, C2 -C5 alkenyl, C2 -C5 alkynyl or the formyl radical; R3 is hydrogen, C1 -C4 alkyl, C1 -C4 alkyl substituted by halogen, cyano or by the radical OR5 or by the radical SR5, C3 -C6 cycloalkyl or C3 -C6 cycloalkyl mono- to tri-substituted by C1 -C4 alkyl or by halogen; R4 is halogen; C1 -C3 alkyl, C1 -C2 haloalkyl, C1 -C3 alkoxy or C1 -C3 haloalkoxy; R5 is hydrogen, C1 -C5 alkyl, C3 -C5 alkenyl, C3 -C5 alkynyl or the radical (CH2)n -X-C1 -C3 -alkyl; R7 is the group -NH2, STR2 and where R8 -R11 are as defined hereafter.
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- 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines.
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6-Aryl-2,3-dihydroimidazo[2,1-b]thiazoles and corresponding thiazines act as nucleophiles, either directly or in the form of Grignard reagents, with N-acylpyridinium salts to produce new 6-aryl-5-(N-acyl-1,4-dihydro-4-pyridyl)-2,3-dihydroimidazo-[2,1-b]thiazoles and corresponding thiazines. These are oxidized to give the corresponding pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines, which are active as inhibitors of the 5-lipoxygenase pathway of arachidonic acid metabolism.
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- 3H imidazo[1'2':2,2]pyrrolo[3,4-b]pyridine-2,5-dione, useful as herbicidal agents
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This continuation-in-part is directed to novel pyridine compounds of formula I below have good selective herbicidal properties pre- and postemergence and also influence or inhibit plant growth. The compounds are of formula I STR1 wherein each of X, Y and Z independently of one another is hydrogen or a C1 -C4 alkyl group, or two adjacent substituents together also form a saturated or unsaturated 3- or 4-membered alkylene chain or alkenyl chain, each of which chains may in turn by substituted by one to four C1 -C4 alkyl groups and R is a C1 -C4 nitroalkyl group.
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- Compounds of the pregnane series with an oxygen function in the 19-position, processes for their manufacture and pharmaceutical preparations containing these compounds
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19-Oxygenated steroid compounds of the pregnane series of the formula I STR1 in which R1 represents a hydrogen atom, and R2 represents an α-oriented lower alkanoylthio group, or R1 and R2 together represent a carbon-carbon bond or an α-or β-oriented methylene radical, R3 represents a free hydroxymethyl group or a hydroxymethyl group etherified by a lower alkyl or esterified by a lower alkanoyl; or represents a formyl group, a carboxyl group or a lower alkoxycarbonyl group, and R4 represents a hydrogen atom or the acyl radical Ac of a carboxylic acid, and corresponding 1,2-dehydro derivatives have valuable aldosterone-antagonizing properties with a minimum effect on sexual functions. As the compounds reduce the excessive sodium retention and potassium excretion induced by aldosterone, they are especially useful as the active ingredient in pharmaceutical preparations for alleviating diseases involving hyperaldosteronismus in man and other warm-blooded animals.
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- Bicyclopentanoid sesquiterpenes. The synthesis of cedranoid sesquiterpenes via the photo-rearrangement of bicyclo[2.2.2]octenones
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(±) - exo - 2,6,6 - Trimethyltricyclo[5.3.1.01.5]undecanc - 8,10 - dione (11) has been synthesized from dimethyl 6,6 - dimethyl - 5 - oxobicyclo[2.2.2]oct - 7 - ene dicarboxylate (17). This constitutes a new synthesis of cedrol(3) since 11 has previously been converted to this compound.
- Yates, Peter,Stevens
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p. 4401 - 4410
(2014/12/10)
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- Pyrazinoisoquinolines as anthelmintic agents
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(-)-2-Benzoyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline is prepared by benzoylation of (-)-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline, or cyclization of a compound of the formula SPC1 Wherein X is F, Cl, Br, I or O-tosyl and which has the optical configuration of the final product, or cyclization of a compound of the formula SPC2 wherein Y is OH, alkoxy, F, Cl, Br or I under HY-removing reaction conditions and which has the optical configuration of the final product, which is an anthelmintic.
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- Intermediates for producing prostaglandins
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Prostaglandin F1α, prostaglandin F1β, and analogs of those are produced from bicyclo[3.1.0]hexane intermediates.
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