865189-98-6

Basic information

• Product Name: 6-Chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one
• Synonyms: 6-Chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one
• CAS NO: 865189-98-6
• Molecular Formula: C₁₆H₁₃ClO
• Molecular Weight: 256.72682
• Mol File: 865189-98-6.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one(865189-98-6)
• EPA Substance Registry System: 6-Chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one(865189-98-6)

Safety Data

• Hazardous Substances Data: 865189-98-6(Hazardous Substances Data)

Usage

Chemical compound

6-chloro-3-(p-tolyl)-2,3-dihydro-1H-inden-1-one

Class

Indenone derivatives

Physical appearance

White to off-white solid

Solubility

Insoluble in water, soluble in organic solvents

Molecular weight

268.72 g/mol

Uses

Building block in the synthesis of pharmaceuticals, agrochemicals, and organic compounds

Structure

Chloro-substituted indenone ring system with a p-tolyl group

Upstream product

• 24393-52-0 ethyl (E)-3-(4-chlorophenyl)prop-2-enoate 
• 108-88-3 toluene 
• 104-88-1 4-chlorobenzaldehyde 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 68185-97-7 (3-chlorophenyl)(trimethylsilyl)methanone 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 

Relevant articles and documents

Gold(I)-Catalyzed Addition of Silylacetylenes to Acylsilanes: Synthesis of Indanones by C-H Functionalization through a Gold(I) Carbenoid

A gold(I)-catalyzed synthesis of indanones from trimethylsilylacetylenes and acylsilanes is presented. The reaction is initiated through a synergistic acylsilane activation-gold acetylide formation and involves consecutive alkyne σ-gold(I) addition, π-activation, and 1,2-migration of a silyl group. Studies performed on the reaction mechanism allowed to establish the nature of the silyl migrating group and invoke the participation of a gold(I) carbenoid intermediate. The reaction is completed by a gold(I) C-H functionalization step.

Superacid-promoted dual C-C bond formation by Friedel-Crafts alkylation and acylation of ethyl cinnamates: Synthesis of indanones

A superacid (triflic acid) promoted dual C-C bond formation via intermolecular Friedel-Crafts alkylation (Michael addition type) and intramolecular acylation for the efficient synthesis of 3-substituted indan-1-ones is presented. This method was successful in activating ethyl cinnamates towards dual aromatic electrophilic substitution. Moreover, it enabled us to synthesize novel spirotetracyclic systems. Georg Thieme Verlag Stuttgart · New York.

PHENYL INDAN DERIVATIVES

This invention relates to novel compounds which are glycine transporter inhibitors and as such effective in the treatment of disorders in the CNS, such as schizophrenia.