865760-13-0

Basic information

• Product Name: Ethanone, 1-(6-benzofuranyl)-
• Synonyms: Ethanone, 1-(6-benzofuranyl)-;1-(benzofuran-6-yl)ethanone
• CAS NO: 865760-13-0
• Molecular Formula: C10H8O2
• Molecular Weight: 160.17
• Mol File: 865760-13-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(6-benzofuranyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(6-benzofuranyl)-(865760-13-0)
• EPA Substance Registry System: Ethanone, 1-(6-benzofuranyl)-(865760-13-0)

Safety Data

• Hazardous Substances Data: 865760-13-0(Hazardous Substances Data)

Upstream product

• 73898-23-4 1-(3-hydroxy-4-iodophenyl)ethan-1-one 
• 1066-54-2 trimethylsilylacetylene 
• 13411-48-8 1-(trimethylsilyl)ethanone 
• 128851-73-0 6-bromo-benzofuran 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 133720-60-2 7-bromobenzo(b)furan 
• 865760-02-7 4'-allyl-3'-(2''-chloroethoxy)acetophenone 
• 58621-54-8 1-(3-(allyloxy)phenyl)ethan-1-one 
• 121-71-1 3-Hydroxyacetophenone 
• 58621-38-8 4'-allyl-3'-hydroxyacetophenone 

Relevant articles and documents

Pyrimidine-containing tri-substituted imidazole compound and application thereof

The invention relates to a pyrimidine-containing tri-substituted imidazole compound and application thereof. The compound has a structure shown as a formula (I). The compound can be used for effectively inhibiting EGFR (epidermal growth factor receptor) C797S mutation including EGFR ex19del/T790M/C797S and L858R/T790M/C797S; meanwhile, the compounds also have high inhibitory activity on single-point mutation L858R, ex19del and double-point mutation such as L858R/T790M, ex19del/T790M and the like, and moreover, the compounds have a weak inhibitory effect on wild EGFR (epidermal growth factor receptor), namely, the compounds have very good selectivity. The compound has potential to become a drug for treating malignant tumors carrying EGFR C797S mutation, especially non-small cell lung cancer(NSCLC), and has great application value.

Base-Mediated Meerwein-Ponndorf-Verley Reduction of Aromatic and Heterocyclic Ketones

An experimental protocol to achieve the Meerwein-Ponndorf-Verley (MPV) reduction of ketones under mildly basic conditions is reported. The transformation is tolerant of a range of ketone substrates, including O- and S-containing heterocycles, is scalable, and shows potential to be used as a platform to access enantioenriched products. These studies provide a general method for achieving the reduction of ketones under mildly basic conditions and offer an alternative protocol to more well-known Al-based MPV reduction conditions.

CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER

[Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

A new synthesis of benzofurans from phenols via claisen rearrangement and ring-closing metathesis

Based on Claisen rearrangement, the double bond isomerization of O-allyl function together with the formation of O-vinyl function in one pot, and ring-closing metathesis (RCM), various phenols were transformed into various benzofurans in good yields.