869886-90-8

Basic information

• Product Name: 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
• Synonyms: 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid
• CAS NO: 869886-90-8
• Molecular Formula: C₁₃H₁₄ClN₃O₂
• Molecular Weight: 279.72216
• Mol File: 869886-90-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid(869886-90-8)
• EPA Substance Registry System: 4-(5-chloro-2-(isopropylaMino)pyridin-4-yl)-1H-pyrrole-2-carboxylic acid(869886-90-8)

Safety Data

• Hazardous Substances Data: 869886-90-8(Hazardous Substances Data)

Upstream product

• 659731-48-3 5-chloro-2-fluoro-4-iodopyridine 
• 869886-87-3 5-chloro-4-iodo-N-isopropylpyridin-2-amine 
• 405230-81-1 2,5-dichloro-4-nitropyridine-1-oxide 
• 40740-41-8 methyl 4-iodo-1H-pyrrole-2-carboxylic acid ester 
• 53976-62-8 2,5-dichloro-1-oxido-pyridin-1-ium 
• 72652-33-6 4-iodo-2-(trichloroacetyl)pyrrole 
• 869886-92-0 4-(5-chloro-2-isopropylamino-pyridin-4-yl)-1-(2,4,6-trimethyl-benzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester N-oxide 
• 869886-86-2 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-p-toluenesulfonyl-1H-pyrrole-2-carboxylate 
• 869886-84-0 C₅H₂BrCl₂NO 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 16110-09-1 2,5 dichloropyridine 
• 869886-85-1 4-iodo-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-89-5 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(2,4,6-trimethylbenzenesulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-88-4 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 

Downstream Products

• 1956366-10-1 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylicacid[1-(3-chlorophenyl)-2-hydroxyethyl]amide hydrochloride 
• 869886-67-9 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 

Relevant articles and documents

ERK INHIBITOR AND USE THEREOF

Disclosed are a compound (as shown in formula I) as an extracellular signal-regulated kinase (ERK) inhibitor, a pharmaceutical composition thereof, a preparation method therefor, and use thereof in treating ERK-mediated diseases. Said compound plays a role by regulating a plurality of processes such as cell proliferation, apoptosis, migration and angiogenesis.

CRYSTALLINE FORMS OF C21H22CI2N4O2

The present invention provides crystalline forms of a compound of formula (I). Also provided are pharmaceutical compositions that include the provided crystalline forms and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer. It has been discovered that crystalline forms of 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1 H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyl]amide can be prepared which exhibit improved properties, e.g. surprisingly improved stability and improved solubility characteristics. Thus, the present invention provides crystalline 4-(5-Chloro-2- isopropylaminopyridin-4-yl)-1H-pyrrole-2-carboxylic acid [1 -(3-chlorophenyl)-2- hydroxyethyljamide.

CRYSTALLINE C21H22C12N4O2 MALONATE

The present invention provides a malonate salt of a compound of formula (I), which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.

PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.