40740-41-8

Usage

Uses

Used in Organic Synthesis:
4-Iodopyrrole-2-carboxylic acid methyl ester is utilized as a synthetic intermediate for the preparation of complex organic molecules. Its unique structure allows for versatile chemical reactions, facilitating the construction of diverse chemical libraries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Iodopyrrole-2-carboxylic acid methyl ester is employed as a key building block for the synthesis of pharmaceuticals. Its presence in the molecular structure can impart specific biological activities, making it instrumental in the discovery of new drugs.
Used in Drug Discovery and Development:
4-Iodopyrrole-2-carboxylic acid methyl ester is used as a precursor in drug discovery and development processes. Its potential to form biologically active compounds positions it as a crucial component in the creation of novel therapeutic agents.
Used in Agrochemicals:
In the agrochemical industry, 4-Iodopyrrole-2-carboxylic acid methyl ester is used as a starting material for the synthesis of various agrochemicals. Its ability to be modified and incorporated into different chemical frameworks makes it a valuable asset in developing new pesticides and other agricultural chemicals.
Used in Chemical Research:
4-Iodopyrrole-2-carboxylic acid methyl ester is a widely studied compound in chemical research. Its unique properties and reactivity are of interest to scientists who aim to understand and exploit its potential in creating new chemical entities and exploring its behavior in various chemical reactions.

InChI:InChI=1/C6H6INO2/c1-10-6(9)5-2-4(7)3-8-5/h2-3,8H,1H3

Upstream product

• 67-56-1 methanol 
• 72652-33-6 4-iodo-2-(trichloroacetyl)pyrrole 
• 124-41-4 sodium methylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 194796-31-1 C₁₉H₁₄Cl₂I₂N₂O₄ 
• 2436-96-6 1-nitro-2-(2-nitrophenyl)benzene 
• 52635-93-5 methyl 4-(2-nitrophenyl)-1H-pyrrole-2-carboxylate 
• 869886-85-1 4-iodo-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-88-4 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carboxylic acid methyl ester 
• 869886-86-2 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)-1-p-toluenesulfonyl-1H-pyrrole-2-carboxylate 
• 869886-67-9 4-[5-chloro-2-[(1-methylethyl)amino]-4-pyridinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide 
• 869886-90-8 4-(5-chloro-2-isopropylaminopyridin-4-yl)-1H pyrrole-2-carboxylic acid 
• 1973505-15-5 t-butyl 7-iodo-3,4-dihydropyrrolo[1,2-a]pyrazine-2(1H)-carboxylate 
• 40740-42-9 4-iodo-1-methyl-pyrrole-2-carboxylic acid methyl ester 
• 194796-32-2 C₁₇H₁₂Cl₂N₂O₄ 
• 903560-42-9 methyl 4-phenyl-1H-pyrrole-2-carboxylate 
• 903560-51-0 methyl 5-chloro-4-iodo-1H-pyrrole-2-carboxylate 
• 90433-90-2 methyl 4-(prop-1-en-2-yl)-1H-pyrrole-2-carboxylate 

Relevant academic research and scientific papers

RESORCINOL DERIVATIVE AS HSP90 INHIBITOR

The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.

Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.

Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide

An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including biologically active compounds and molecular imaging agents.

Mild arming and derivatization of natural products via an In(OTf) 3-catalyzed arene iodination

Figure presented Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)3 at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.

BICYCLO-SUBSTITUTED PYRAZOLON AZO DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF

The bicyclo-substituted pyrazolon-azo derivatives of formula (I) or pharmaceutical acceptable salts, hydrates or solvates thereof, methods for their preparation, pharmaceutical compositions containing the same and their use as a therapeutic agent, especially as thrombopoietin (TPO) mimetics and their use as agonists of thrombopoietin receptor are disclosed. The definition of substituents in formula (I) are the same as defined in the description.

Amino-5-(5-membered)hetero-arylimidazolone compounds and the use thereof for beta-secretase modulation

The present invention provides a 2-amino-5-heteroaryl-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles

The regioselective synthesis of aryl pyrroles

Pyrrole is a unique aromatic molecule as it can readily undergo substitution at all five positions but obtaining the desired regioisomer can prove difficult to control. We now report our results on the regioselective arylation of pyrrole, utilizing select

PYRROLE COMPOUNDS AS INHIBITORS OF ERK PROTEIN KINASE, SYNTHESIS THEREOF AND INTERMEDIATES THERETO

The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (1): STR1 in which X is one of the radicals: STR2 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof

Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): STR1 wherein Ar is a radical having one of the formulae (a)-(i): STR2 and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.