870194-63-1

Basic information

• Product Name: 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-
• Synonyms: 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-
• CAS NO: 870194-63-1
• Molecular Formula: C₁₄H₁₂ClNO₅
• Molecular Weight: 309.7
• Mol File: 870194-63-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-(870194-63-1)
• EPA Substance Registry System: 4-Isoxazolecarboxylic acid, 3-[2-chloro-4-(2-methoxy-2-oxoethyl)phenyl]-5-methyl-(870194-63-1)

Safety Data

• Hazardous Substances Data: 870194-63-1(Hazardous Substances Data)

Upstream product

• 870194-62-0 3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid tert-butyl ester 
• 870194-52-8 (3-chloro-4-formylphenyl)acetic acid methyl ester 
• 496856-45-2 (3-chloro-4-cyanophenyl)acetic acid methyl ester 
• 870194-53-9 [3-chloro-4-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester 
• 496856-44-1 methyl 2-(3-chloro-4-(triuoromethylsulfonyloxy)phenyl)acetate 
• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 57017-95-5 methyl 3-chloro-4-hydroxyphenylacetate 
• 34841-49-1 3-chloro-4-formylbenzeneacetic acid 

Downstream Products

• 1047643-60-6 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethoxymethyl]-5-phenyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 919283-66-2 (4-{4-[2-(2,4-bis-trifluoromethyl-phenoxy)-ethylcarbamoyl]-5-methyl-isoxazol-3-yl}-3-chloro-phenyl)-acetic acid methyl ester 
• 919283-27-5 (3-chloro-4-{5-methyl-4-[2-(2-nitro-4-trifluoromethyl-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 919283-31-1 (3-chloro-4-{5-methyl-4-[2-(4-trifluoromethyl-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 919283-67-3 (3-chloro-4-{4-[2-(2,4-dichloro-phenoxy)-ethylcarbamoyl]-5-methyl-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 919283-29-7 (3-chloro-4-{5-methyl-4-[2-(2-nitro-phenoxy)-ethylcarbamoyl]-isoxazol-3-yl}-phenyl)-acetic acid methyl ester 
• 870194-61-9 [3-chloro-4-(4-chlorocarbonyl-5-methyl-isoxazol-3-yl)-phenyl]-acetic acid methyl ester 

Relevant articles and documents

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.

COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS

The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR .