872619-43-7

Basic information

• Product Name: Methyl 5-bromo-7-azaindole-3-carboxylate
• Synonyms: Methyl 5-bromo-7-azaindole-3-carboxylate;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-broMo-, Methyl ester;Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylate;5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester
• CAS NO: 872619-43-7
• Molecular Formula: C₉H₇BrN₂O₂
• Molecular Weight: 255.06808
• Mol File: 872619-43-7.mol

Chemical Properties

• Appearance: /
• Density: 1.709±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.33±0.40(Predicted)
• CAS DataBase Reference: Methyl 5-bromo-7-azaindole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-bromo-7-azaindole-3-carboxylate(872619-43-7)
• EPA Substance Registry System: Methyl 5-bromo-7-azaindole-3-carboxylate(872619-43-7)

Safety Data

• Hazardous Substances Data: 872619-43-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Methyl 5-bromo-7-azaindole-3-carboxylate is used as a building block in organic synthesis for its ability to contribute to the formation of more complex molecules. Its unique structure and reactivity make it a versatile component in the synthesis of various organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Methyl 5-bromo-7-azaindole-3-carboxylate is utilized as a key intermediate for the development of pharmaceuticals. Its incorporation into drug molecules can enhance their efficacy and selectivity, contributing to the advancement of novel therapeutic agents.
Used in Pharmaceutical Development:
Methyl 5-bromo-7-azaindole-3-carboxylate is employed as a component in the development of pharmaceuticals due to its potential biological activity. Its unique properties allow it to be a subject of ongoing research aimed at discovering new drugs with improved therapeutic profiles.
Used in Agrochemical Production:
Methyl 5-bromo-7-azaindole-3-carboxylate is also used in the production of agrochemicals, where its reactivity and structural features can be leveraged to create more effective and targeted pesticides or other agricultural products.
Used in Advanced Materials Research:
Methyl 5-bromo-7-azaindole-3-carboxylate is utilized in the research and development of advanced materials, where its unique chemical properties can be harnessed to create innovative materials with specialized applications in various industries.

Upstream product

• 67-56-1 methanol 
• 849068-61-7 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid 
• 35486-42-1 2-amino-3,5-dibromopyridine 
• 76-02-8 trifluoroacetyl chloride 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 

Downstream Products

• 1200130-72-8 1-benzenesulfonyl-5-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 
• 1200130-80-8 9-benzenesulfonyl-5-bromo-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-78-4 9-benzenesulfonyl-5-hydroxy-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrole-6-carbonitrile 
• 1200130-79-5 1,1,2,2,3,3,4,4,4-nonafluorobutanesulfonic acid 9-benzenesulfonyl-6-cyano-3-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b:4',3'-d]pyrrol-5-yl ester 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 1200130-71-7 1-benzenesulfonyl-5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester 

Relevant articles and documents

PYRROLOPYRIMIDINE ITK INHIBITORS

Disclosed herein are arylpyridinone compounds and compositions useful in the treatment of ITK mediated diseases, such as inflammation, having the structures of Formulas (I)-(IV): wherein the R groups, m, n, and X are as defined in the detailed description. Methods of inhibition of ITK activity in a human or animal subject are also provided.

Synthetic method of 5-bromo-7-azaindole

The invention discloses a synthetic method of 5-bromo-7-azaindole. According to the synthetic method, 2, 5-dibromo-2-aminopyridine and 3, 3-diethoxy methyl propionate are subjected to synthesis so asto obtain (E)-3-((3, 5-dibromopyridine-2-yl)imino)methyl propionate; and (E)-3-((3, 5-dibromopyridine-2-yl)imino)methyl propionate is subjected to synthesis so as to obtain 5-bromo-1H-pyrrole [2, 3-b] pyrimidine-3-methyl carboxylate; and 5-bromo-1H-pyrrole [2, 3-b] pyrimidine-3-methyl carboxylate is subjected to synthesis so as to obtain 5-bromo-7-azaindole. Reaction steps are few; operation is convenient; reaction steps are high in yield; industrialized production can be realized; quintal grade production can be realized; and relatively high product yield is ensured.

THERAPEUTIC INHIBITORY COMPOUNDS

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.

PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL, PYRROLO[2,3-B]PYRIDINYL ACRYLAMIDES AND EPOXIDES THEREOF

The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3- b]pyrazinyl,and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides,and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention

NEW DERIVATIVES OF 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXAMIDE OR 5-ARYL-1H-PYRROLO [2, 3B] PYRIDINE-3-CARBOXYLIC ACID

The present invention relates to new compounds of formula I as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containin