874668-62-9

Basic information

• Product Name: 6-BENZYLOXY-1H-INDAZOLE
• Synonyms: 6-BENZYLOXY-1H-INDAZOLE
• CAS NO: 874668-62-9
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• Product Categories: pharmacetical
• Mol File: 874668-62-9.mol

Chemical Properties

• Boiling Point: 422.407°C at 760 mmHg
• Flash Point: 152.493°C
• Appearance: /
• Density: 1.247g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.678
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.22±0.40(Predicted)
• CAS DataBase Reference: 6-BENZYLOXY-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BENZYLOXY-1H-INDAZOLE(874668-62-9)
• EPA Substance Registry System: 6-BENZYLOXY-1H-INDAZOLE(874668-62-9)

Safety Data

• Hazardous Substances Data: 874668-62-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-BENZYLOXY-1H-INDAZOLE is used as a building block for the synthesis of biologically active molecules and pharmaceutical intermediates, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
6-BENZYLOXY-1H-INDAZOLE is used as a component in the development of agrochemicals, potentially enhancing crop protection and yield.
Used in Materials Science:
6-BENZYLOXY-1H-INDAZOLE is used in the research and development of new materials with specific properties, such as conductivity, stability, or reactivity.
Used in Organic Synthesis:
6-BENZYLOXY-1H-INDAZOLE is used as a reagent in organic synthesis, facilitating the creation of diverse molecular structures for various applications.
Used in Chemical Reactions:
6-BENZYLOXY-1H-INDAZOLE is used as a substrate in chemical reactions, enabling the formation of new compounds with potential applications in various fields.
Used in Antimicrobial Applications:
6-BENZYLOXY-1H-INDAZOLE is studied for its potential antimicrobial properties, which could be utilized in the development of new antimicrobial agents to combat resistant bacteria and other pathogens.
Used in Antitumor Applications:
6-BENZYLOXY-1H-INDAZOLE is investigated for its potential antitumor activities, which may contribute to the development of novel cancer therapies and treatments.

InChI:InChI=1/C14H12N2O/c1-2-4-11(5-3-1)10-17-13-7-6-12-9-15-16-14(12)8-13/h1-9H,10H2,(H,15,16)

Upstream product

• 52085-14-0 4-benzoxy-salicylaldehyde 
• 23244-88-4 1H-indazol-6-ol 
• 100-39-0 benzyl bromide 

Downstream Products

• 210581-14-9 (R)-1-(6-benzyloxy-indazol-1-yl)-propan-2-ol 
• 478132-22-8 (S)-1-(6-benzyloxyindazol-1-yl)propan-2-ol 
• 853921-69-4 [(S)-2-(6-hydroxy-7-hydroxymethyl-indazol-1-yl)-1-methylethyl]-carbamic acid benzyl ester 
• 874668-76-5 [(S)-2-(7-Fluoro-6-hydroxy-indazol-1-yl)-1-methyl-ethyl]-carbamic acid benzyl ester 
• 874668-77-6 [(S)-2-(7-Chloro-6-hydroxy-indazol-1-yl)-1-methyl-ethyl]-carbamic acid benzyl ester 
• 478132-53-5 [(S)-2-(6-hydroxyindazol-1-yl)-1-methylethyl]carbamic acid benzyl ester 
• 874668-74-3 [(S)-2-(6-Methoxy-indazol-1-yl)-1-methyl-ethyl]-carbamic acid benzyl ester 
• 210581-27-4 1-(2-azido-propyl)-6-benzyloxy-1H-indazole 

Relevant articles and documents

Synthesis, antifungal activity and qsar of novel pyrazole amides as succinate dehydrogenase inhibitors

We design and synthesize a series of novel pyrazole amides based on the commercialized fungicides and our previous work. The antifungal activity was tested in vitro by mycelial growth inhibition assay. The results show that all the compounds are of antifungal activities against the tested fungi at different levels. Among them, N-(2-(7-bromo-5-chloro-1H-indazol-1-yl)phenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide (Vk) exhibited higher antifungal activity than boscalid against two fungi. Molecular docking study revealed that the carbonyl oxygen atom of Vk forms two hydrogen bonds toward the hydroxyl hydrogens of TYR58 and TRP173.

Two-step N-acylindazole to N-alkylindazole reduction. Further synthetic studies on the serotonergic agonist AL-34662

A synthesis of the title compound, operable on kilogram scale, employs reductive acetylation of an N-acylindazole to give a hemiaminal acetate followed by deacetoxylation to the corresponding N-alkylindazole.

1-((S)-2-aminopropyl)-1H-indazol-6-ol: A potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity

Serotonin 5-HT2 receptor agonists have been identified as a potential new class of agents for the treatment of ocular hypertension and glaucoma. The initially reported tryptamine analogues displayed either poor solution stability, potent centra