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874804-31-6

2-FLUORO-4-METHOXYBENZAMIDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 874804-31-6 Structure

  • Basic information

    1. Product Name: 2-FLUORO-4-METHOXYBENZAMIDE
    2. Synonyms: 2-FLUORO-4-METHOXYBENZAMIDE
    3. CAS NO:874804-31-6
    4. Molecular Formula: C8H8FNO2
    5. Molecular Weight: 169.1530232
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 874804-31-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2-FLUORO-4-METHOXYBENZAMIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-FLUORO-4-METHOXYBENZAMIDE(874804-31-6)
    11. EPA Substance Registry System: 2-FLUORO-4-METHOXYBENZAMIDE(874804-31-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 874804-31-6(Hazardous Substances Data)

874804-31-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 874804-31-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,8,0 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 874804-31:
(8*8)+(7*7)+(6*4)+(5*8)+(4*0)+(3*4)+(2*3)+(1*1)=196
196 % 10 = 6
So 874804-31-6 is a valid CAS Registry Number.

874804-31-6Relevant articles and documents

Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia

Jagtap, Ajit Dhananjay,Chang, Pei-Teh,Liu, Jia-Rong,Wang, Hsiao-Chun,Kondekar, Nagendra B.,Shen, Li-Jiuan,Tseng, Hsiang-Wen,Chen, Grace Shiahuy,Chern, Ji-Wang

supporting information, p. 268 - 288 (2014/08/18)

A series of 6-acylureido derivatives containing a 3-(pyrrol-2- ylmethylidene)indolin-2-one scaffold were synthesized as potential dual Aurora B/FLT3 inhibitors by replacing the 6-arylureido moiety in 6-arylureidoindolin-2- one-based multi-kinase inhibitors. (Z)-N-(2-(pyrrolidin-1-yl)ethyl)-5-((6-(3-(2- fluoro-4-methoxybenzoyl)ureido)-2-oxoindolin-3-ylidene)methyl)-2, 4-dimethyl-1H-pyrrole-3-carboxamide (54) was identified as a dual Aurora B/FLT3 inhibitor (IC50 = 0.4 nM and 0.5 nM, respectively). Compound 54 also exhibited potent cytotoxicity with single-digit nanomolar IC50 values against the FLT3 mutant-associated human acute myeloid leukemia (AML) cell lines MV4-11 (FLT3-ITD) and MOLM-13 (FLT3-ITD). Compound 54 also specifically induced extrinsic apoptosis by inhibiting the phosphorylation of the Aurora B and FLT3 pathways in MOLM-13 cells. Compound 54 had a moderate pharmacokinetic profile. The mesylate salt of 54 efficiently inhibited tumor growth and reduced the mortality of BALB/c nude mice (subcutaneous xenograft model) that had been implanted with AML MOLM-13 cells. Compound 54 is more potent than sunitinib not only against FLT3-WT AML cells but also active against sunitinib-resistant FLT3-ITD AML cells. This study demonstrates the significance of dual Aurora B/FLT3 inhibitors for the development of potential agents to treat AML.

NOVEL 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES HAVING BOTH AROMATIC AND HALOGENIC SUBSTITUENTS

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Paragraph 0537-0540, (2014/03/24)

Certain 4,6-disubstituted aminopyrimidine derivatives having both aromatic and halogenic substituents.

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