- Synthesis of a novel tricyclic 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system and CXCR4 antagonists with potent activity against HIV-1
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Stereorandom and diastereoselective syntheses of a novel 1,2,3,4,4a,5,6,10b-octahydro-1,10-phenanthroline ring system are described. Derivatives of all four diastereomers were prepared and isolated in >98% ee. The pure enantiomers were compared in order t
- Catalano, John G.,Gudmundsson, Kristjan S.,Svolto, Angilique,Boggs, Sharon D.,Miller, John F.,Spaltenstein, Andrew,Thomson, Michael,Wheelan, Pat,Minick, Doug J.,Phelps, Dean P.,Jenkinson, Stephen
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experimental part
p. 2186 - 2190
(2010/07/05)
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- CHEMICAL COMPOUNDS
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There is provided novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as C
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Page/Page column 34
(2008/06/13)
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- CHEMICAL COMPOUNDS
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The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a recep
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Page/Page column 130-131
(2010/11/08)
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- CHEMICAL COMPOUNDS
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The present invention provides compounds of Formula (I) comprising: including salts, solvates, and physiologically functional derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
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Page/Page column 45
(2008/06/13)
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