2-(CHLOROMETHYL)-5-FLUOROIMIDAZO[1,2-A]PYRIDINE

Base Information

• Chemical Name: 2-(CHLOROMETHYL)-5-FLUOROIMIDAZO[1,2-A]PYRIDINE
• CAS No.: 878198-71-1
• Molecular Formula: C8H6ClFN2
• Molecular Weight: 184.6
• Mol file: 878198-71-1.mol

Synonyms:S14-0048;2-(chloromethyl)-5-fluoro-imidazol[1,2-a]pyridine;2-(chloromethyl)-5-fluoroH-imidazo[1,2-a]pyridine;

Chemical Property of 2-(CHLOROMETHYL)-5-FLUOROIMIDAZO[1,2-A]PYRIDINE

Chemical Property:

• PSA: 17.30000
• LogP: 2.21220

Purity/Quality:

99% ^*data from raw suppliers

2-(Chloromethyl)-5-fluoroimidazo[1,2-a]pyridine 95% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-(CHLOROMETHYL)-5-FLUOROIMIDAZO[1,2-A]PYRIDINE

There total 1 articles about 2-(CHLOROMETHYL)-5-FLUOROIMIDAZO[1,2-A]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6-fluoro-pyridin-2-ylamine (1597-32-6) + 1,3-Dichloroacetone (534-07-6) → 2-(chloromethyl)-5-fluoroimidazo[1,2-a]pyridine (878198-71-1)

Guidance literature:

In ethyl acetate; at 65 ℃; for 15h;

Reference yield: 60.0%

2-(chloromethyl)-5-fluoroimidazo[1,2-a]pyridine (878198-71-1) + (R)-N-((R)-1-(4-methoxyphenyl)ethyl)-5,6,7,8-tetrahydroquinolin-8-amine (876591-02-5) → (8R)-N-[(5-fluoroimidazo[1,2-a]pyridin-2-yl)methyl]-N-{(1R)-1-[4-(methyloxy)phenyl]ethyl}-5,6,7,8-tetrahydro-8-quinolinamine (878198-72-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; potassium iodide; In acetonitrile; at 20 ℃; for 15h;

upstream raw materials:

6-fluoro-pyridin-2-ylamine

1,3-Dichloroacetone

Downstream raw materials:

(8R)-N-[(5-fluoroimidazo[1,2-a]pyridin-2-yl)methyl]-N-{(1R)-1-[4-(methyloxy)phenyl]ethyl}-5,6,7,8-tetrahydro-8-quinolinamine

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