878671-93-3

Basic information

• Product Name: 1-Cyclopropyl-4-nitronaphthalene
• Synonyms: 1-Cyclopropyl-4-nitronaphthalene
• CAS NO: 878671-93-3
• Molecular Formula: C₁₃H₁₁NO₂
• Molecular Weight: 213.23194
• Mol File: 878671-93-3.mol

Chemical Properties

• Boiling Point: 375.2±21.0 °C(Predicted)
• Appearance: /
• Density: 1.305±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Cyclopropyl-4-nitronaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclopropyl-4-nitronaphthalene(878671-93-3)
• EPA Substance Registry System: 1-Cyclopropyl-4-nitronaphthalene(878671-93-3)

Safety Data

• Hazardous Substances Data: 878671-93-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Cyclopropyl-4-nitronaphthalene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Cyclopropyl-4-nitronaphthalene is utilized as a precursor in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Organic Synthesis:
1-Cyclopropyl-4-nitronaphthalene is employed as a starting material in the synthesis of other organic compounds, highlighting its versatility in chemical reactions and its role in creating a diverse range of chemical products.
Used in Laboratory Research:
As a key component in laboratory settings, 1-Cyclopropyl-4-nitronaphthalene is used for the synthesis of derivatives with potential biological and pharmacological activities, contributing to scientific discovery and innovation in the field of chemistry.

Upstream product

• 25033-19-6 1-cyclopropyl-naphthalene 

Downstream Products

• 878671-98-8 2-((5-amino-4-(4-cyclopropyl-naphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid methyl ester 
• 878672-00-5 2-{[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetic acid 
• 1533519-92-4 1-amino-4-cyclopropylnaphthalene hydrochloride 
• 1533519-86-6 N-(4-cyclopropylnaphthalen-1-yl)-2-formylhydrazine-1-thiocarboxamide 
• 1533519-84-4 4-(4-cyclopropylnaphthalen-1-yl)-4Η-1,2,4-triazole-3-thiol 
• 1533519-85-5 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazole-3-yl)thio)acetic acid methyl ester 
• 878672-00-5 (-)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 878672-00-5 (+)-2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid 
• 878671-94-4 1-amino-4-cyclopropylnaphthalene 

Relevant articles and documents

Lesinurad analogue and its preparation method and medical use

The invention relates to a lesinurad analog as shown in the general formula (I), its preparation method, a pharmaceutical composition containing the derivative and an application of the pharmaceutical composition used as a therapeutic agent, especially as a medicine for treating hyperuricemia and gout, wherein definition of each substituent group in the general formula (I) is as the same as definition in the specification.

2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-yl thio)acetic acid intermediates

Lesinurad key intermediate compounds (L-4) and (L-5) are prepared; a preparation method is simple in postprocessing of reaction, the product is relatively high in purity and relatively good in stability, the preparation method is suitable for industrialized production, and a new simple and feasible method is provided for preparation of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-yl thio)acetic acid key intermediate compound (L-6) and a final finished product raw material medicine thereof; the pollution to the environment is reduced, the product yield and quality of the prepared raw material medicine are improved to a great extent, and medicine industrialization costs are reduced.

Optically pure thioacetic compound

The invention belongs to the field of pharmacy and relates to an optically pure thioacetic compound and application thereof to medicine. The optically pure thioacetic compound comprises levorotatory 2-(5-bromo-4-(4-cyclopropyl-naphthalene-1-base)-4H-1,2,4-triazole-3-based sulfenyl) acetic acid and dextral 2-(5-bromo-4-(4-cyclopropyl-naphthalene-1-base)-4H-1,2,4-triazole-3-based sulfenyl) acetic acid.

MANUFACTURE OF 2- (5- BROMO-4 (-CYCLOPROPYLNAPHTHALEN-1-YL) -4H-1,2,4-TRIAZOL-3-YLTHIO) ACETIC ACID

Described herein are certain processes for the synthesis of compounds of Formula (I):

POLYMORPHIC, CRYSTALLINE AND MESOPHASE FORMS OF SODIUM 2-(5-BROMO-4-(4-CYCLOPROPYLNAPHTHALEN-1-YL)-4H-1,2,4-TRIAZOL-3-YLTHIO)ACETATE, AND USES THEREOF

Crystalline polymorphs and solid mesophase forms of sodium 2-(5-bromo-4- (4-cyclopropylnaphthalen-l-yl)-4H-l,2,4-triazol-3-ylthio)acetate are described. In addition, pharmaceutical compositions and uses of such compositions for the treatment of a variety of diseases and conditions are provided.

NOVEL COMPOUNDS AND COMPOSITIONS AND METHODS OF USE

Described herein are compounds useful in the modulation of blood uric, acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders relafed to aberrant levels of uric acid

S-TRIAZOLYL α-MERCAPTOACETANILDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE

A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.