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5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is a complex chemical compound that is a carboxamide derivative of pyridine. It features bromine, chlorine, methoxy, and methyl functional groups, which contribute to its unique chemical properties. 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is widely recognized for its potential biological activity and serves as a key intermediate in the synthesis of various pharmaceuticals. Its significance in medicinal and organic chemistry is underscored by its versatile applications.

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  • 885223-63-2 Structure
  • Basic information

    1. Product Name: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide
    2. Synonyms: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide;N-Methoxy-N-methyl 5-bromo-2-chloronicotinamide;5-broMo-2-chloro-N-Methoxy-N-MethylnicotinaMide
    3. CAS NO:885223-63-2
    4. Molecular Formula: C8H8BrClN2O2
    5. Molecular Weight: 279.51832
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 885223-63-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(885223-63-2)
    11. EPA Substance Registry System: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide(885223-63-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 885223-63-2(Hazardous Substances Data)

885223-63-2 Usage

Uses

Used in Organic Synthesis:
5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is utilized as a reagent in organic synthesis for its ability to participate in a variety of chemical reactions, facilitating the creation of new compounds with potential applications across different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide is employed as a key intermediate. Its role is crucial in the development and preparation of various pharmaceuticals, where its unique structure and functional groups can be leveraged to design and synthesize new drugs with specific therapeutic properties.
Given the provided materials, there are no specific applications detailed beyond its use as a reagent in organic synthesis and as an intermediate in pharmaceutical research. However, the compound's potential biological activity suggests that it may also be explored for direct therapeutic uses in medicine, pending further research and development.

Check Digit Verification of cas no

The CAS Registry Mumber 885223-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,2 and 3 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 885223-63:
(8*8)+(7*8)+(6*5)+(5*2)+(4*2)+(3*3)+(2*6)+(1*3)=192
192 % 10 = 2
So 885223-63-2 is a valid CAS Registry Number.

885223-63-2Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

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Paragraph 1296; 1297, (2021/03/19)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

CERTAIN PROTEIN KINASE INHIBITORS

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Paragraph 153; 154; 190; 191, (2017/12/27)

Provided are certain CDK4/6 inhibitors, pharmaceutical compositions thereof, and methods of use therefor.

Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors

Lin, Songwen,Han, Fangbin,Liu, Peng,Tao, Jing,Zhong, Xuechao,Liu, Xiujie,Yi, Chongqin,Xu, Heng

supporting information, p. 790 - 793 (2014/02/14)

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1,6-naph

Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives

Han, Fangbin,Lin, Songwen,Liu, Peng,Tao, Jing,Yi, Chongqin,Xu, Heng

supporting information, p. 4538 - 4541 (2015/02/06)

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway by PI3K/mTOR dual inhibitors provides a promising new approach to the treatment of cancers. In this Letter, we identified structurally novel and

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

Huart, Anne-Sophie,Saxty, Barbara,Merritt, Andy,Nekulova, Marta,Lewis, Stephen,Huang, Yide,Vojtesek, Borivoj,Kettleborough, Catherine,Hupp, Ted R.

supporting information, p. 5578 - 5585 (2013/10/01)

Reactivation of the wild-type p53 pathway is one key goal aimed at developing targeted therapeutics in the cancer research field. Although most p53 protein kinases form 'p53-activating' signals, there are few kinases whose action can contribute to the inhibition of p53, as Casein kinase 1 (CK1) and Checkpoint kinase 1 (CHK1). Here we report on a pyrazolo-pyridine analogue showing activity against both CK1 and CHK1 kinases that lead to p53 pathway stabilisation, thus having pharmacological similarities to the p53-activator Nutlin-3. These data demonstrate the emerging potential utility of multivalent kinase inhibitors.

PYRAZOLE COMPOUNDS

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Page/Page column 102-104, (2009/03/07)

The present invention is directed to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

THIADIAZOLE COMPOUNDS AND METHODS OF USE

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Page/Page column 43-44, (2010/11/08)

The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated

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