5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide

Base Information

• Chemical Name: 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide
• CAS No.: 885223-63-2
• Molecular Formula: C9H11ClN2O2
• Molecular Weight: 279.51800
• Hs Code.: 2933399090
• Mol file: 885223-63-2.mol

Synonyms:5-bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide;

Chemical Property of 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide

Chemical Property:

• PSA: 42.43000
• LogP: 2.13090
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Methoxy-N-methyl5-bromo-2-chloronicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide

There total 3 articles about 5-Bromo-2-chloro-N-methoxy-N-methylpyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5-bromo-2-chloronicotinic acid (29241-65-4) + N,0-dimethylhydroxylamine (1117-97-1) → 5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2)

Guidance literature:

5-bromo-2-chloronicotinic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

N,0-dimethylhydroxylamine; In dichloromethane; at 20 ℃;

Reference yield: 81.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 5-bromo-2-chloronicotinic acid (29241-65-4) → 5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2)

Guidance literature:

5-bromo-2-chloronicotinic acid; With thionyl chloride; at 80 ℃; for 2h;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

→ 5-bromo-2-chloro-N-methoxy-N-methylnicotinamide (885223-63-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 1.25h;

upstream raw materials:

5-bromo-2-chloronicotinic acid

N,0-dimethylhydroxylamine

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

5-bromo-2-chloropyridine-3-carbaldehyde

5-bromo-2-chloro-3-(dimethoxymethyl)pyridine

N-(5-(2-amino-4-methylpyrido[2,3-d]pyrimidin-6-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide

1-(5-bromo-2-chloropyridin-3-yl)ethanone

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