885229-41-4Relevant articles and documents
PREPARATION OF 2-CHLORO-1-(2-CHLOROTHIAZOL-5-YL)ETHANONE
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Page/Page column 13-14, (2021/04/10)
The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.
Second generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn's disease
Chalopin,Alvarez Dorta,Sivignon,Caudan,Dumych,Bilyy,Deniaud,Barnich,Bouckaert,Gouin
, p. 3913 - 3925 (2016/05/19)
The anti-adhesive strategy, consisting of disrupting bacterial attachment to the host cells, is widely explored as an alternative to antibiotic therapies. Recently, thiazolylmannosides (TazMans) have been identified as strong anti-adhesives of E. coli strains implied in the gut inflammation of patients with Crohn's disease. In this work, we developed a second generation of TazMans with improved chemical stability. The anomeric nitrogen was substituted by short linkers and the compounds were assessed against the bacterial adhesin FimH and the clinically isolated LF82 E. coli strain in four in vitro assays. The results obtained on the FimH adhesin alone and the whole bacteria enabled the identification of a candidate for further in vivo evaluations.
MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG
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Page/Page column 133; 134, (2014/02/16)
The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:
HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS
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Page/Page column 74; 75, (2010/08/04)
The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.
Thieno-pyrimidine compounds having fungicidal activity
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Page/Page column 10, (2008/06/13)
The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.
THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY
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Page/Page column 33, (2008/06/13)
The present invention relates to thieno[2,3-d]-pyrimidine compounds of Formula (I) having fungicidal activity.
AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE
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Page/Page column 33, (2010/11/08)
The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.
Thieno-pyrimidine compounds having fungicidal activity
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Page/Page column 35, (2010/11/08)
The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.