885229-41-4

Basic information

• Product Name: 1-(2-chlorothiazol-5-yl)ethanone
• Synonyms: 1-(2-chlorothiazol-5-yl)ethanone;2-chloro-5-acetylthiazole
• CAS NO: 885229-41-4
• Molecular Formula: C₅H₄ClNOS
• Molecular Weight: 161.60936
• EINECS: -0
• Mol File: 885229-41-4.mol

Chemical Properties

• Boiling Point: 273.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.397±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.23±0.10(Predicted)
• CAS DataBase Reference: 1-(2-chlorothiazol-5-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chlorothiazol-5-yl)ethanone(885229-41-4)
• EPA Substance Registry System: 1-(2-chlorothiazol-5-yl)ethanone(885229-41-4)

Safety Data

• Hazardous Substances Data: 885229-41-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-chlorothiazol-5-yl)ethanone is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure and reactivity allow it to participate in a wide range of chemical reactions, making it a valuable component in the development of new medications with diverse therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-(2-chlorothiazol-5-yl)ethanone serves as an intermediate for the production of various agrochemicals. Its potential as a building block in the development of new compounds with biological activity and medicinal properties makes it a promising candidate for creating innovative solutions in agriculture.
Used in Organic Chemistry Research:
1-(2-chlorothiazol-5-yl)ethanone is also of interest in the field of organic chemistry research. Its reactivity and potential applications in the development of new synthetic methods and strategies contribute to the advancement of chemical science and the creation of novel compounds with potential applications in various industries.

Upstream product

• 3034-52-4 2-chlorothiazole 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 53159-71-0 1-(2-aminothiazol-5-yl)ethanone 
• 1234014-27-7 2-chloro-N-methoxy-N-methyl-1,3-thiazole-5-carboxamide 
• 676-58-4 methylmagnesium chloride 
• 40982-18-1 1-(2-chloro-thiazol-5-yl)-ethanol 

Downstream Products

• 478259-73-3 1-(2-(4-(trifluoromethyl)phenylamino)thiazol-5-yl)ethanone 
• 893434-25-8 1-(2-phenylsulfanyl-thiazol-5-yl)-ethanone 

Relevant articles and documents

PREPARATION OF 2-CHLORO-1-(2-CHLOROTHIAZOL-5-YL)ETHANONE

The present invention relates to a process for the preparation 2-chloro-1-(2-chlorothiazol-5-yl)ethanone.

Second generation of thiazolylmannosides, FimH antagonists for E. coli-induced Crohn's disease

The anti-adhesive strategy, consisting of disrupting bacterial attachment to the host cells, is widely explored as an alternative to antibiotic therapies. Recently, thiazolylmannosides (TazMans) have been identified as strong anti-adhesives of E. coli strains implied in the gut inflammation of patients with Crohn's disease. In this work, we developed a second generation of TazMans with improved chemical stability. The anomeric nitrogen was substituted by short linkers and the compounds were assessed against the bacterial adhesin FimH and the clinically isolated LF82 E. coli strain in four in vitro assays. The results obtained on the FimH adhesin alone and the whole bacteria enabled the identification of a candidate for further in vivo evaluations.

MULTIMERIC MANNOSIDES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG

The present invention relates to multimeric mannosides, a process for preparing the same and their uses in medicine for treating Escherichia Coli infections. Exemplary compounds are:

HETEROARYL COMPOUNDS USEFUL AS RAF KINASE INHIBITORS

The present invention provides compounds of formula (I) useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf -mediated diseases.

Thieno-pyrimidine compounds having fungicidal activity

The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

THIENO-PYRIMIDINE COMPOUNDS HAVING FUNGICIDAL ACTIVITY

The present invention relates to thieno[2,3-d]-pyrimidine compounds of Formula (I) having fungicidal activity.

Thieno-pyrimidine compounds having fungicidal activity

The present invention relates to thieno[2,3-d]-pyrimidine compounds having fungicidal activity.

AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.