887401-92-5

Basic information

• Product Name: INCB 3284
• Synonyms: N-({1-[4-Hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexyl]-pyrrolidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide;INCB-003284
• CAS NO: 887401-92-5
• Molecular Formula: C₂₆H₃₁F₃N₄O₄
• Molecular Weight: 520.5439496
• Mol File: 887401-92-5.mol

Chemical Properties

• Boiling Point: 703.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 12.94±0.46(Predicted)
• CAS DataBase Reference: INCB 3284(CAS DataBase Reference)
• NIST Chemistry Reference: INCB 3284(887401-92-5)
• EPA Substance Registry System: INCB 3284(887401-92-5)

Safety Data

• Hazardous Substances Data: 887401-92-5(Hazardous Substances Data)

Upstream product

• 226228-88-2 (R)-N-(2-(1-benzylpyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide 
• 226249-16-7 (R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)-ethyl)-3-(trifluoromethyl)benzamide 
• 708273-57-8 4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 708273-56-7 8-(6-methoxy-pyridin-3-yl)-1,4-dioxa-spiro[4.5]decan-8-ol 
• 17794-48-8 m-trifluoromethylhippuric acid 

Downstream Products

• 887401-93-6 N-[2-({(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide dimethanesulfonate 

Relevant articles and documents

Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist

We report the identification of 13 (INCB3284) as a potent human CCR2 (hCCR2) antagonist. INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC 50 of 4.7 nM in antagonism of c