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Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. It is an effective medication that inhibits plasma ACE activity and decreases blood pressure in various animal models, making it a promising pharmaceutical candidate for the treatment of hypertension.

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  • 88768-40-5 Structure
  • Basic information

    1. Product Name: Cilazapril
    2. Synonyms: CILASTATIN NA;CILASTATIN SODIUM SALT;sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate;6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-;6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-;Ro 31-2848;Yipingshu;(1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
    3. CAS NO:88768-40-5
    4. Molecular Formula: C22H31N3O5
    5. Molecular Weight: 417.5
    6. EINECS: 279-694-4
    7. Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;API
    8. Mol File: 88768-40-5.mol
  • Chemical Properties

    1. Melting Point: 95-97°C
    2. Boiling Point: 598.1 °C at 760 mmHg
    3. Flash Point: 315.5 °C
    4. Appearance: Off-White Solid
    5. Density: 1.26 g/cm3
    6. Vapor Pressure: 3.73E-15mmHg at 25°C
    7. Refractive Index: 1.591
    8. Storage Temp.: 2-8°C
    9. Solubility: Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
    10. CAS DataBase Reference: Cilazapril(CAS DataBase Reference)
    11. NIST Chemistry Reference: Cilazapril(88768-40-5)
    12. EPA Substance Registry System: Cilazapril(88768-40-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: 22-24/25
    4. WGK Germany: 3
    5. RTECS: MJ9650200
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 88768-40-5(Hazardous Substances Data)

88768-40-5 Usage

Uses

Used in Pharmaceutical Industry:
Cilazapril is used as an ACE inhibitor for the treatment of hypertension. It is hydrolyzed in vivo to the active diacid metabolite, cilazaprilat, which helps in lowering blood pressure and managing hypertension in patients. Formulations containing cilazapril have been widely used in the treatment of hypertension, providing an effective therapeutic option for individuals suffering from high blood pressure.

Check Digit Verification of cas no

The CAS Registry Mumber 88768-40-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,7,6 and 8 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 88768-40:
(7*8)+(6*8)+(5*7)+(4*6)+(3*8)+(2*4)+(1*0)=195
195 % 10 = 5
So 88768-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1

88768-40-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid

1.2 Other means of identification

Product number -
Other names (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:88768-40-5 SDS

88768-40-5Relevant articles and documents

PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF CILAZAPRIL

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, (2012/05/04)

The present invention relates to a process for the preparation of optically pure (S,S)-6-t-butoxycarbonyl-hexahydro-1-pyridazinylcarbonyl-1,3-dioxo-2-isoindolebutyric acid, an intermediate for the preparation of cilazapril.

A NOVEL PROCESS FOR THE PREPARATION OF CILAZAPRIL

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Page 4-5, (2008/06/13)

Cilazapril is prepared in good yield using ethyl R-2-(nitro or halo substituted benzene sulfonyloxy)-4-phenyl butyrate. Thus, (1S,9S)-t-butyl octahydro-10-oxo-9-amino-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylate is reacted with ethyl R-2-(4-nitro benz

ENANTIOMERICALLY PURE CILAZAPRIL,PROCESS FOR PREPARATION

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Page 5-6, (2008/06/13)

The invention relates to enantiomerically pure cilazapril and a process for preparing enantiomerically pure cilazapril. The invention also relates to pharmaceutical compositions that include the enantiomerically pure cilazapril and use of said composition

The Design and Synthesis of the Angiotensin Converting Enzyme Inhibitor Cilazapril and Related Bicyclic Compounds

Attwood, Michael R.,Hassall, Cedric H.,Kroehn, Antonin,Lawton, Geoffrey,Redshaw, Sally

, p. 1011 - 1020 (2007/10/02)

The postulated binding functions for the active site of Angiotensin Converting Enzyme (A.C.E.), derived in an earlier study, have made possible the design of improved inhibitors.Consequently, (1S,9S)-9-octahydro-10-oxo-6H-pyridazodiazepine-1-carboxylic acid (Cilazapril), and related compounds, have been synthesized.They are very active inhibitors of A.C.E. and are highly potent antihypertensives in vivo.

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