72064-51-8

Usage

Uses

Used in Pharmaceutical Synthesis:
(S)-1-benzyl-3-tert-butyl piperazine-1,3-dicarboxylate serves as an intermediate in the synthesis of other pharmaceutical compounds, leveraging its unique structure and functional groups to facilitate the creation of new medicinal entities.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (S)-1-benzyl-3-tert-butyl piperazine-1,3-dicarboxylate is employed as a versatile building block, enabling the design and synthesis of innovative pharmaceuticals with potential therapeutic applications across different medical disciplines.

InChI:InChI=1/C17H24N2O4/c1-17(2,3)23-15(20)14-10-7-11-19(18-14)16(21)22-12-13-8-5-4-6-9-13/h4-6,8-9,14,18H,7,10-12H2,1-3H3/t14-/m0/s1

Upstream product

• 65632-62-4 (3S)-hexahydro-1,3-pridazinedicarboxylic acid 1-(phenylmethyl) ester 
• 115-11-7 isobutene 
• 156699-38-6 (4S)-3-<(3S)-N,N'-bis(t-butoxycarbonyl)hexahydropyridazine-3-carboxy>-4-phenylmethyl-2-oxazolidinone 
• 156699-39-7 (3S)-N,N'-bis-(t-butoxycarbonyl)hexahydropyridazine-3-carboxylic acid 
• 156699-37-5 (S)-4-benzyl-3-(5-bromopentanoyl)oxazolidine-2-one 
• 4509-90-4 5-bromovaleroyl chloride 

Downstream Products

• 153428-05-8 (S)-2-[(R)-2-(2,2,2-Trichloro-ethoxycarbonylmethyl)-octanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 153428-15-0 (S)-2-[(R)-2-(2,2,2-Trichloro-ethoxycarbonylmethyl)-nonanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 153427-94-2 (S)-2-[(R)-2-(2,2,2-Trichloro-ethoxycarbonylmethyl)-decanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 163389-09-1 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(2R)-1-oxo-2-<(2,2,2-trichloroethoxycarbonyl)methyl>undecyl>hexahydropyridazine-3-carboxylate 
• 153428-25-2 (S)-2-[(R)-2-(2,2,2-Trichloro-ethoxycarbonylmethyl)-dodecanoyl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 173469-54-0 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(3R)-3-(2,2,2-trichloroethoxycarbonyl)-1-oxooctyl>hexahydropyridazine-3-carboxylate 
• 173469-55-1 tert-butyl (3S)-1-benzyloxycarbonyl-2-<(3S)-3-(2,2,2-trichloroethoxycarbonyl)-1-oxooctyl>hexahydropyridazine-3-carboxylate 
• 88824-62-8 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88767-97-9 (1S,9S)-t-butyl 9-<(1R)-ethoxycarbonyl-3-phenylpropylamino>octahydro-6,10-dioxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106927-97-3 (1S,9S)-t-butyl octahydro-10-oxo-9-phthalimido-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-19-9 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-10-oxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 106860-20-2 9-amino-octahydro-10-oxo-6H-pyridazo[1,2-a][1,2]diazepine-1-(S)carboxylic acid t-butyl ester 
• 88768-40-5 cilazapril 
• 234752-71-7 3-[(9-benzoylamino-6,10-dioxo-octahydro-pyridazino[1,2-a][1,2]diazepine-1-carbonyl)-amino]-N-methoxy-N-methyl-succinamic acid tert-butyl ester 

Relevant academic research and scientific papers

An efficient stereoselective synthesis of [3S(1S,9S)]-3-[[[9- (benzoylamino)octahydro-6,10-dioxo-6H-pyridazino-(1,2-a)(1,2)-diazepin-1- yl]-carbonyl]amino]-4-oxobutanoic acid, an interleukin converting enzyme (ICE) inhibitor

The title compound 1 is a potent interleukin-1β-converting enzyme (ICE) inhibitor. Recently, an efficient chiral synthesis of compound 1 has been accomplished in our labs. The overall yield of this 18-step stereoselective synthesis was 9.8%.