cas 89028-40-0, (R)-(-)-3-PROPIONYL-4-ISOPROPYL-2-OXAZOLIDINONE

Articles about 89028-40-0Total 5 be found

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
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Paragraph 000331; 000332

(2021/03/02)

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
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Page/Page column 11; 174-175

(2019/07/17)

Structural Determination of (-)-SCH 64874 and Hirsutellomycin by Semisynthesis
The structure of a C2-symmetric epidithiodiketopiperazine alkaloid, SCH 64874, was determined by semisynthesis. The relative stereochemistry of the β-hydroxy carboxylic acid chain having three chiral centers was determined by comparison of the NMR data of the four possible diastereomeric β-hydroxy carboxylic acid fragments with those of SCH 64874. Condensation of the (-)-deacetylaranotin core with two enantiomeric β-hydroxy carboxylic acids revealed the relative stereochemistry of SCH 64874. The relative stereochemistry of the β-keto carboxylic acid chain of the analogous alkaloid hirsutellomycin was determined in a stepwise manner. The C4′-C6′ syn relationships were predicted by comparing the NMR data of the corresponding ester fragments with that of hirsutellomycin. The relative stereochemistry of the whole molecule, including the epimerizable C2′ stereocenter, was determined by introduction of four possible side chains into the bisdethiodi(methylthio)deacetylaranotin core. We found that the stereochemistry of C2′ converged with that of the thermodynamically stable form influenced by the core structure.
Tokuyama, Hidetoshi,Yamada, Kaori,Fujiwara, Hideto,Sakata, Juri,Okano, Kentaro,Sappan, Malipan,Isaka, Masahiko
p. 353 - 371
(2017/04/26)

Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.
Perry, Matthew A.,Trinidad, Jonathan V.,Rychnovsky, Scott D.
supporting information
p. 472 - 475
(2013/04/11)

Asymmetric alkylations using SuperQuat auxiliaries - An investigation into the synthesis and stability of enolates derived from 5,5-disubstituted oxazolidin-2-ones
Studies on the alkylation of enolates derived from a range of N-acyl-5,5-dimethyloxazolidin-2-ones and N-acyl-5,5-diphenyloxazolidin-2-ones reveal that high yields and high diastereoselectivities are best obtained when homochiral 4-isopropyl-5,5-dimethyloxazolidin-2-one is employed as a chiral auxiliary.
Bull, Steven D.,Davies, Stephen G.,Jones, Simon,Sanganee, Hitesh J.
p. 387 - 398
(2007/10/03)