894803-87-3

Basic information

• Product Name: Methyl 4-aMino-6-ethoxypicolinate
• Synonyms: Methyl 4-aMino-6-ethoxypicolinate;4-Amino-6-ethoxy-2-pyridinecarboxylic acid methyl ester;METHYL 4-AMINO-6-ETHOXYPYRIDINE-2-CARBOXYLATE;4-aMino-6-ethoxypyridine-2-carboxylic acid Methyl ester
• CAS NO: 894803-87-3
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.20318
• Mol File: 894803-87-3.mol

Chemical Properties

• Appearance: /
• Density: 1.201
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Methyl 4-aMino-6-ethoxypicolinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-aMino-6-ethoxypicolinate(894803-87-3)
• EPA Substance Registry System: Methyl 4-aMino-6-ethoxypicolinate(894803-87-3)

Safety Data

• Hazardous Substances Data: 894803-87-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-amino-6-ethoxypicolinate is used as a building block in the synthesis of various pharmaceuticals for its potential applications in the development of new drugs.
Used in Agrochemical Industry:
Methyl 4-amino-6-ethoxypicolinate is used in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
Methyl 4-amino-6-ethoxypicolinate is used as an intermediate in the preparation of biologically active compounds, playing a crucial role in the creation of diverse chemical entities with potential therapeutic or commercial value.

Upstream product

• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 904311-14-4 2-chloro-6-ethoxy-pyridin-4-amine 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 

Downstream Products

• 916673-05-7 4-Amino-6-ethoxy-5-((Z)-2-trimethylsilanyl-but-1-en-3-ynyl)-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide 
• 916673-06-8 4-amino-2-ethoxy-6-(4-methanesulfonyl-benzylcarbamoyl)-nicotinic acid methyl ester 
• 904312-12-5 4-amino-6-ethoxy-5-iodo-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide 
• 904311-45-1 4-amino-5-chloro-6-ethoxy-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide 

Relevant articles and documents

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer's disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ and showed little inhibitory activity against a panel of 74 kinases.

Inhibitors of c-Jun N-terminal kinases

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.