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Methyl 4-amino-6-ethoxypicolinate, also known as 4-Amino-6-Ethoxy-Nicotinic Acid Methyl Ester, is a chemical compound with the molecular formula C10H13N2O3. It is a derivative of nicotinic acid and is commonly used in the synthesis of pharmaceuticals and agrochemicals. Methyl 4-aMino-6-ethoxypicolinate is a yellowish-brown solid with a molecular weight of 211.22 g/mol. It is used as a building block in organic synthesis and can be utilized in the production of various pharmaceuticals and fine chemicals. Methyl 4-amino-6-ethoxypicolinate has potential applications in the development of new drugs and can serve as an intermediate in the preparation of biologically active compounds.

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  • 894803-87-3 Structure
  • Basic information

    1. Product Name: Methyl 4-aMino-6-ethoxypicolinate
    2. Synonyms: Methyl 4-aMino-6-ethoxypicolinate;4-Amino-6-ethoxy-2-pyridinecarboxylic acid methyl ester;METHYL 4-AMINO-6-ETHOXYPYRIDINE-2-CARBOXYLATE;4-aMino-6-ethoxypyridine-2-carboxylic acid Methyl ester
    3. CAS NO:894803-87-3
    4. Molecular Formula: C9H12N2O3
    5. Molecular Weight: 196.20318
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 894803-87-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.201
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 4-aMino-6-ethoxypicolinate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 4-aMino-6-ethoxypicolinate(894803-87-3)
    11. EPA Substance Registry System: Methyl 4-aMino-6-ethoxypicolinate(894803-87-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 894803-87-3(Hazardous Substances Data)

894803-87-3 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 4-amino-6-ethoxypicolinate is used as a building block in the synthesis of various pharmaceuticals for its potential applications in the development of new drugs.
Used in Agrochemical Industry:
Methyl 4-amino-6-ethoxypicolinate is used in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Synthesis:
Methyl 4-amino-6-ethoxypicolinate is used as an intermediate in the preparation of biologically active compounds, playing a crucial role in the creation of diverse chemical entities with potential therapeutic or commercial value.

Check Digit Verification of cas no

The CAS Registry Mumber 894803-87-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,4,8,0 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 894803-87:
(8*8)+(7*9)+(6*4)+(5*8)+(4*0)+(3*3)+(2*8)+(1*7)=223
223 % 10 = 3
So 894803-87-3 is a valid CAS Registry Number.

894803-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 4-amino-6-ethoxypyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names 4-Amino-6-ethoxy-2-pyridinecarboxylic acid methyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:894803-87-3 SDS

894803-87-3Relevant articles and documents

Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond

Liu, Gang,Zhao, Hongyu,Liu, Bo,Xin, Zhili,Liu, Mei,Kosogof, Christi,Szczepankiewicz, Bruce G.,Wang, Sanyi,Clampit, Jill E.,Gum, Rebecca J.,Haasch, Deanna L.,Trevillyan, James M.,Sham, Hing L.

, p. 5723 - 5730 (2007/10/03)

The structure-activity relationships of 5,6-positions of aminopyridine carboxamide-based c-Jun N-terminal Kinase (JNK) inhibitors were explored to expand interaction with the kinase specificity and ribose-binding pockets. The syntheses of analogues and the impact of structural modification on in vitro potency and cellular activity are described.

Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity

Szczepankiewicz, Bruce G.,Kosogof, Christi,Nelson, Lissa T. J.,Liu, Gang,Liu, Bo,Zhao, Hongyu,Serby, Michael D.,Xin, Zhili,Liu, Mei,Gum, Rebecca J.,Haasch, Deanna L.,Wang, Sanyi,Clampit, Jill E.,Johnson, Eric F.,Lubben, Thomas H.,Stashko, Michael A.,Olejniczak, Edward T.,Sun, Chaohong,Dorwin, Sarah A.,Haskins, Kristi,Abad-Zapatero, Cele,Fry, Elizabeth H.,Hutchins, Charles W.,Sham, Hing L.,Rondinone, Cristina M.,Trevillyan, James M.

, p. 3563 - 3580 (2007/10/03)

The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family of enzymes. They are activated in response to certain cytokines, as well as by cellular stresses including chemotoxins, peroxides, and irradiation. They have been implicated in the pathology of a variety of different diseases with an inflammatory component including asthma, stroke, Alzheimer's disease, and type 2 diabetes mellitus. In this work, high-throughput screening identified a JNK inhibitor with an excellent kinase selectivity profile. Using X-ray crystallography and biochemical screening to guide our lead optimization, we prepared compounds with inhibitory potencies in the low-double-digit nanomolar range, activity in whole cells, and pharmacokinetics suitable for in vivo use. The new compounds were over 1000-fold selective for JNK-1 and -2 over other MAP kinases including ERK2, p38α, and p38δ and showed little inhibitory activity against a panel of 74 kinases.

Inhibitors of c-Jun N-terminal kinases

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Page/Page column 38; 63, (2008/06/13)

The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

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