Methyl 4-aMino-6-ethoxypicolinate

Base Information

• Chemical Name: Methyl 4-aMino-6-ethoxypicolinate
• CAS No.: 894803-87-3
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.206
• Hs Code.: 2933399090
• Mol file: 894803-87-3.mol

Synonyms:4-Amino-6-ethoxy-2-pyridinecarboxylic acid methyl ester;Methyl 4-amino-6-ethoxypicolinate;4-amino-6-ethoxypyridine-2-carboxylic acid methyl ester;2-Pyridinecarboxylic acid,4-amino-6-ethoxy-,methyl ester;

Chemical Property of Methyl 4-aMino-6-ethoxypicolinate

Chemical Property:

• PSA: 74.44000
• Density: 1.201
• LogP: 1.43030
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-amino-6-ethoxypicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aMino-6-ethoxypicolinate

There total 2 articles about Methyl 4-aMino-6-ethoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-chloro-6-ethoxy-pyridin-4-amine (904311-14-4) + methanol (67-56-1) + carbon monoxide (201230-82-2) → 4-amino-6-ethoxypyridine-2-carboxylic acid methyl ester (894803-87-3)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; at 100 ℃; for 6h; under 5171.48 Torr;

DOI:10.1021/jm060199b

Reference yield:

2,6-dichloro-[4]pyridylamine (2587-02-2) → 4-amino-6-ethoxypyridine-2-carboxylic acid methyl ester (894803-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 2 h / 150 °C

2: PdCl₂(dppf) / 4 h / 100 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol;

DOI:10.1016/j.bmcl.2006.08.097

Reference yield:

4-amino-6-ethoxypyridine-2-carboxylic acid methyl ester (894803-87-3) → 4-amino-5-chloro-6-ethoxy-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide (904311-45-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 48 percent / N-chlorosuccinimide / dimethylformamide / 72 h / 20 °C

2: aq. LiOH / ethanol / 0.5 h

3: TBTU; Et₃N / dimethylformamide / 16 h / 20 °C

With lithium hydroxide; N-chloro-succinimide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm060465l

upstream raw materials:

2-chloro-6-ethoxy-pyridin-4-amine

methanol

carbon monoxide

2,6-dichloro-[4]pyridylamine

Downstream raw materials:

4-amino-5-chloro-6-ethoxy-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide

4-amino-6-ethoxy-5-iodo-N-[4-(methylsulfonyl)benzyl]pyridine-2-carboxamide

4-amino-2-ethoxy-6-(4-methanesulfonyl-benzylcarbamoyl)-nicotinic acid methyl ester