898788-78-8

Basic information

• Product Name: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE
• Synonyms: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE
• CAS NO: 898788-78-8
• Molecular Formula: C15H12Cl2O
• Molecular Weight: 279.16
• Mol File: 898788-78-8.mol

Chemical Properties

• Boiling Point: 401.3°C at 760 mmHg
• Flash Point: 169.6°C
• Appearance: /
• Density: 1.257g/cm³
• Vapor Pressure: 1.19E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE(898788-78-8)
• EPA Substance Registry System: 2',4'-DICHLORO-3-PHENYLPROPIOPHENONE(898788-78-8)

Safety Data

• Hazardous Substances Data: 898788-78-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2',4'-Dichloro-3-phenylpropiophenone is used as a key intermediate in the synthesis of various medications. Its unique chemical structure allows it to be a building block for developing new pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2',4'-Dichloro-3-phenylpropiophenone is utilized as an intermediate for the production of pesticides. Its role in creating effective pest control agents is vital for ensuring agricultural productivity and crop protection.

InChI:InChI=1/C15H12Cl2O/c16-12-7-8-13(14(17)10-12)15(18)9-6-11-4-2-1-3-5-11/h1-5,7-8,10H,6,9H2

Upstream product

• 100-52-7 benzaldehyde 
• 2234-16-4 1-(2,4-dichlorophenyl)ethan-1-one 

Downstream Products

• 1621006-63-0 5-benzyl-4-(2,4-dichlorophenyl)thiazol-2-amine 
• 1621006-48-1 5-benzyl-4-(2,4-dichlorophenyl)-N-(4-methoxybenzyl)thiazol-2-amine 

Relevant articles and documents

Efficient synthesis of 3-aryl-5-chloroindan-1-ones via free radical-mediated intramolecular cyclization

An efficient free radical-mediated intramolecular cyclization strategy has been developed for the synthesis of 3-aryl-5-chloroindan-1-ones. Variously substituted 2,4-dichloroenones afforded 3-aryl-5-chloroindan-1-ones in quantitative yields upon intramole

2,4,5-Trisubstituted thiazole derivatives: A novel and potent class of non-nucleoside inhibitors of wild type and mutant HIV-1 reverse transcriptase

Novel 2,4,5-trisubstituted thiazole derivatives (TSTs) were designed and synthesized as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Among the thirty-eight synthesized target compounds, thirty TSTs showed potent inhibition against HIV-1 replication in wild type HIV-1 at submicromolar concentrations (from 0.046 to 9.59 μM). Compounds 21, 23 and 24 were also tested on seven NNRTI-resistant HIV-1 strains, and all exhibited inhibitory effects with fold changes in IC50 ranging from 2.6 to 111, which were better than those of nevirapine (15.6-fold-371-fold). Docking simulations of compound 24 revealed a reasonable mechanism for the binding mode, and three-dimensional quantitative structure activity relationship (3-DQSAR) studies on this novel series of TST further elucidated the structure-activity relationship (SAR). The results suggested the great potential of TSTs as a novel class of NNRTIs with antiviral efficacy and a good resistance profile.