903499-35-4

Basic information

• Product Name: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
• Synonyms: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-;1-Methyl-7-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-indole
• CAS NO: 903499-35-4
• Molecular Formula: C15H20BNO2
• Molecular Weight: 257.139
• Mol File: 903499-35-4.mol

Chemical Properties

• Melting Point: 95 °C(Solv: hexane (110-54-3))
• Boiling Point: 391.3±15.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-(903499-35-4)
• EPA Substance Registry System: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-(903499-35-4)

Safety Data

• Hazardous Substances Data: 903499-35-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole, 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is used as a synthetic intermediate for the development of novel drugs. Its unique structure and reactivity allow for the creation of new pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
1H-Indole, 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)is used as a precursor in the production of agricultural chemicals. Its versatile reactivity enables the synthesis of new agrochemicals with potential applications in crop protection and pest control.
Further research into the properties and potential uses of 1H-Indole, 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)may reveal additional applications in various fields, expanding its utility and significance in the scientific community.

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 280752-68-3 7-bromo-1-methylindole 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 51417-51-7 7-bromo-1H-indole 

Relevant articles and documents

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An exclusive catalytic C4-selective fluoroalkylation of indoles with highly active (1H, 1H-perfluoroalkyl)mesityliodonium triflate has been described. The key to its high regioselectivity is the appropriate choice of an easily accessible, cheap and removable directing group at the C3 position in the presence of a Pd(OAc)2 catalyst. Besides indole fluoroalkylation, the application of this strategy in other heteroarenes such as benzo[b]thiophene is also described.

Convenient synthesis of 1H-indol-1-yl boronates via palladium(0)-catalyzed borylation of bromo-1H-indoles with 'pinacolborane'

An atom-economic Pd0-catalyzed synthesis of a series of pinacol-type indolylboronates 3 from the corresponding bromoindole substrates 2 and pinacolborane (pinBH) as borylating agent was elaborated. The optimal catalyst system consisted of a 1:2 mixture of [Pd(OAc)2] and the ortho-substituted biphenylphosphine ligand L-3 (Scheme 4, Table). Our synthetic protocol was applied to the fast, preparative-scale synthesis of 1-substituted indolylboronates 3a-h in the presence of different functional groups, and at a catalyst load of only 1 mol-% of Pd.