1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Base Information

• Chemical Name: 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-
• CAS No.: 903499-35-4
• Molecular Formula: C₁₅H₂₀BNO₂
• Molecular Weight: 257.14
• Hs Code.: 2933998090
• Mol file: 903499-35-4.mol

Synonyms:

Chemical Property of 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Chemical Property:

• Melting Point: 95 °C(Solv: hexane (110-54-3))
• Boiling Point: 391.3±15.0 °C(Predicted)
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1H-Indole,1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

There total 4 articles about 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4,4,5,5-tetramethyl-1,3,2-dioxaborolane + 7-bromo-1-methylindole (280752-68-3) → 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (903499-35-4)

Guidance literature:

With triethylamine; palladium diacetate; CyJohnPhos; In 1,4-dioxane; at 80 ℃;

DOI:10.1002/hlca.200690097

Reference yield: 74.0%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + 7-bromo-1-methylindole (280752-68-3) → 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (903499-35-4)

Guidance literature:

With palladium diacetate; triethylamine; In 1,4-dioxane; under Ar atm.; Schlenk flask charged with Pd(CH3COO)2 and P(C6H11)2(C6H4C6H5); evapd.; filled (Ar); 1,4-dioxane added; stirred for 30 min at room temp.; Et3N added; soln. of bromoindole in dioxane added; neat pinacolborane added; stirred at 80°C; cooled to room temp.; Celite and activated charcoal added; stirred for 15 min; filtered; solvent removed (vac.); residue diluted (cyclohexane); filtered through a short pad of neutral alumina; purified by column chromy. (SiO2, cyclohexane/ethyl acetate);

DOI:10.1002/hlca.200690097

Reference yield: 59.0%

bis(pinacol)diborane (73183-34-3) + 7-bromo-1-methylindole (280752-68-3) → 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole (903499-35-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 95 ℃; for 2h; Inert atmosphere;

upstream raw materials:

7-bromo-1-methylindole

7-bromo-1H-indole

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

bis(pinacol)diborane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 903499-35-4 1H-INDOLE, 1-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-

Send

Send

Metric Ton KG G Pound L ML

Send

Send