280752-68-3

Basic information

• Product Name: 7-Bromo-1-methyl-1H-indole 97%
• Synonyms: 7-Bromo-1-methyl-1H-indole 97%;7-BROMO-1-METHYL-1H-INDOLE;7-Bromo-1-methyl-1H-indole97%
• CAS NO: 280752-68-3
• Molecular Formula: C₉H₈BrN
• Molecular Weight: 210.08
• Mol File: 280752-68-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 50.5-53°C
• Boiling Point: 300.878°C at 760 mmHg
• Flash Point: 135.766°C
• Appearance: /
• Density: 1.472g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 7-Bromo-1-methyl-1H-indole 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Bromo-1-methyl-1H-indole 97%(280752-68-3)
• EPA Substance Registry System: 7-Bromo-1-methyl-1H-indole 97%(280752-68-3)

Safety Data

• Hazardous Substances Data: 280752-68-3(Hazardous Substances Data)

Usage

General Description

7-Bromo-1-methyl-1H-indole 97% is a chemical compound that consists of a bromine atom, a methyl group, and an indole ring. It is a white to light yellow crystalline powder with a purity of 97%. 7-Bromo-1-methyl-1H-indole 97% is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its chemical properties make it a valuable intermediate in the production of various drugs and biologically active compounds. It is also utilized in research and development activities in the pharmaceutical and chemical industries. Overall, 7-Bromo-1-methyl-1H-indole 97% is a versatile chemical compound with a wide range of applications in the field of organic synthesis.

InChI:InChI=1/C9H8BrN/c1-11-6-5-7-3-2-4-8(10)9(7)11/h2-6H,1H3

Upstream product

• 51417-51-7 7-bromo-1H-indole 
• 74-88-4 methyl iodide 
• 865-33-8 potassium methanolate 
• 189266-03-3 7-bromo-N-(4-toluenesulfonyl)-1H-indole 
• 577-19-5 2-nitrophenyl bromide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 903499-35-4 1-methyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole 
• 52951-14-1 1-methyl-1H-indole-7-carbonitrile 
• 1426803-88-4 C₂₅H₂₃ClN₂O₃S*C₂HF₃O₂ 
• 1110272-50-8 2,4,6-Trimethyl-N-[(S)-1-(1-methyl-1H-indol-7-ylmethyl)propyl]benzenesulfonamide 
• 408355-01-1 3-(6-Benzyloxy-1H-indol-3-yl)-4-(1-methyl-1H-indol-7-yl)-pyrrole-2,5-dione 

Relevant articles and documents

Preparation method of nitrogen-alkyl (deuterated alkyl) aromatic heterocycle and alkyl (deuterated alkyl) aryl ether compound

The invention provides a method for preparing nitrogen-alkyl(deuterated alkyl)aromatic heterocycle and alkyl(deuterated alkyl)aryl ether compounds. The method adopted in the invention specifically comprises the following steps: firstly, adding an alkoxy base (MOR') or a combination reagent Q (comprising a base M'X, an alcohol C and a molecular sieve E) into a solvent B to be stirred; then, addingan aromatic compound D of nitrogen sulfonyl or oxygen sulfonyl into a mixture; separating and purifying after reaction to obtain nitrogen-alkyl(deuterated alkyl)aromatic heterocycle or alkyl(deuterated alkyl)aryl ether. The method can realize one-step conversion from an electron withdrawing benzenesulfonyl protecting group on a nitrogen or oxygen atom to an electron donating alkyl protecting group, avoids using highly toxic alkyl halide, and has advantages of being efficient, economical, environmentally friendly, mild in condition, good in substrate universality and high in yield; the prepareddeuterated compounds can be widely applied to the fields of pharmaceutical chemistry and organic chemistry synthesis.

Salicylaldehyde-Promoted Cobalt-Catalyzed C-H/N-H Annulation of Indolyl Amides with Alkynes: Direct Synthesis of a 5-HT3 Receptor Antagonist Analogue

A cobalt-catalyzed annulation of the C(sp2)-H/N-H bond of indoloamides with alkynes assisted by 8-aminoquinoline is reported for the synthesis of six-membered indololactams. The use of salicylaldehyde as the ligand is crucial for this transformation. The protocol has a broad scope for both alkynes and indoles. Preparing an active Co complex illustrates that salicylaldehyde plays a key role in the C-H activation step. The synthetic applications are proven by the gram-scale reaction and one-step construction of the multicyclic 5-HT3 receptor antagonist.

Detosylative (Deutero)alkylation of Indoles and Phenols with (Deutero)alkoxides

An efficient strategy for N/O-(deutero)alkylation of indoles and phenols with alkoxides/alcohols as the alkylation reagents is described. The consecutive detosylation/alkylation transformations feature mild reaction conditions, high ipso-selectivity, and good functional group tolerance (>50 examples). A one-pot selective N-alkylation of unprotected indoles with alcohols and TsCl is also realized. The application of this method is demonstrated by the introduction of isotope-labeled (CD3 and 13CH3) groups using the readily accessible labeled alcohols and the synthesis of pharmaceuticals.