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904961-21-3

4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 904961-21-3 Structure

  • Basic information

    1. Product Name: 4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL
    2. Synonyms: 4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL;4-[(5-bromo-1,3-thiazol-2-yl)oxy]phenol
    3. CAS NO:904961-21-3
    4. Molecular Formula: C9H6BrNO2S
    5. Molecular Weight: 272.11844
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 904961-21-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 434 °C at 760 mmHg
    3. Flash Point: 216.3 °C
    4. Appearance: /
    5. Density: 1.815 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. Water Solubility: at 25 deg C (mg/L): 327
    10. CAS DataBase Reference: 4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL(904961-21-3)
    12. EPA Substance Registry System: 4-(5-BROMOTHIAZOL-2-YLOXY)PHENOL(904961-21-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 904961-21-3(Hazardous Substances Data)

904961-21-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 904961-21-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,4,9,6 and 1 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 904961-21:
(8*9)+(7*0)+(6*4)+(5*9)+(4*6)+(3*1)+(2*2)+(1*1)=173
173 % 10 = 3
So 904961-21-3 is a valid CAS Registry Number.

904961-21-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[(5-bromo-1,3-thiazol-2-yl)oxy]phenol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:904961-21-3 SDS

904961-21-3Relevant articles and documents

N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1-methylprop-2-ynyl}carboxy derivatives as acetyl-CoA carboxylase inhibitors - Improvement of cardiovascular and neurological liabilities via structural modifications

Gu, Yu Gui,Weitzberg, Moshe,Clark, Richard F.,Xu, Xiangdong,Li, Qun,Lubbers, Nathan L.,Yang, Yi,Beno, David W. A.,Widomski, Deborah L.,Zhang, Tianyuan,Hansen, T. Matthew,Keyes, Robert F.,Waring, Jeffrey F.,Carroll, Sherry L.,Wang, Xiaojun,Wang, Rongqi,Healan-Greenberg, Christine H.,Blomme, Eric A.,Beutel, Bruce A.,Sham, Hing L.,Camp, Heidi S.

, p. 1078 - 1082 (2008/02/04)

A preliminary safety evaluation of ACC2 inhibitor 1-(S) revealed serious neurological and cardiovascular liabilities of this chemotype. A systematic structure-toxicity relationship study identified the alkyne linker as the key motif responsible for these adverse effects. Toxicogenomic studies in rats showed that 1-(R) and 1-(S) induced gene expression patterns similar to that seen with several known cardiotoxic agents such as doxorubicin. Replacement of the alkyne with alternative linker groups led to a new series of ACC inhibitors with drastically improved cardiovascular and neurological profiles.

Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome

-

Page/Page column 24, (2008/06/13)

The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.

Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Clark, Richard F.,Zhang, Tianyuan,Xin, Zhili,Liu, Gang,Wang, Ying,Hansen, T. Matthew,Wang, Xiaojun,Wang, Rongqi,Zhang, Xiaolin,Frevert, Ernst U.,Camp, Heidi S.,Beutel, Bruce A.,Sham, Hing L.,Gu, Yu Gui

, p. 6078 - 6081 (2007/10/03)

Structure-activity relationships for a recently discovered thiazolyl phenyl ether series of acetyl-CoA carboxylase (ACC) inhibitors were investigated. Preliminary efforts to optimize the series through modification of the distal aryl ether moiety of the l

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