908334-28-1

Basic information

• Product Name: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE
• Synonyms: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE;3-(4-Amino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 908334-28-1
• Molecular Formula: C₁₅H₂₂N₂O₂
• Molecular Weight: 262.35
• Mol File: 908334-28-1.mol

Chemical Properties

• Boiling Point: 397.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.123±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 4.96±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE(908334-28-1)
• EPA Substance Registry System: TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE(908334-28-1)

Safety Data

• Hazardous Substances Data: 908334-28-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 3-(4-AMINOPHENYL)PYRROLIDINE-1-CARBOXYLATE is used as a precursor for the synthesis of various drugs and pharmaceutical products due to its unique chemical structure and potential pharmacological properties. Its versatile molecular design allows for the development of new medications with improved therapeutic effects and reduced side effects.

Upstream product

• 1393901-75-1 tert-butyl 3-(4-nitrophenyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 37595-74-7 N,N-phenylbistrifluoromethane-sulfonimide 
• 24067-17-2 4-nitrophenylboronic acid 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1428760-69-3 C₂₉H₃₂N₂O₂ 
• 1428760-68-2 C₂₉H₃₄N₂O₃ 
• 65145-14-4 N,N-dibenzyl-4-bromoaniline 

Downstream Products

• 1312559-49-1 5-chloropyridine-2-carboxylic acid (4-pyrrolidin-3-yl-phenyl)-amide hydrochloride 
• 1357267-19-6 3-{4-[(5-chloropyridine-2-carbonyl)amino]phenyl}pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1357267-36-7 3-[4-(4-chlorobenzoylamino)phenyl]pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1312559-52-6 1-(5-chloropyridin-2-yl)-3-(4-pyrrolidin-3-yl-phenyl)-urea hydrochloride 
• 1357267-12-9 3-{4-[3-(5-chloropyridin-2-yl)ureido]phenyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1428759-13-0 C₂₈H₂₆ClN₇O₂ 
• 1393901-76-2 tert-butyl 3-(4-((4-chloro-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxylate 
• 1312565-76-6 (RS)-3-{4-[2-(4-chloro-phenyl)-ethoxycarbonylamino]-phenyl}-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1312561-06-0 (RS)-(4-pyrrolidin-3-yl-phenyl)-carbamic acid 2-(4-chloro-phenyl)-ethyl ester 
• 1312559-22-0 (R)-2-phenyl-N-((RS)-4-pyrrolidin-3-yl-phenyl)-propionamide 
• 1312565-58-4 (RS)-3-[4-(4,4-difluoro-cyclohexyloxycarbonylamino)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1312559-54-8 (RS)-(4-pyrrolidin-3-yl-phenyl)-carbamic acid 4,4-difluoro-cyclohexyl ester 
• 1312565-37-9 (RS)-3-(4-phenylacetylamino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 1312565-35-7 (RS)-3-(4-phenoxycarbonylamino-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

NAMPT MODULATORS

Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.

FAK AND FLT3 INHIBITORS

The use of a compound of the formula (I): (Formula (I)) in the preparation of a medicament for treating Acute Myeloid Leukemia or a disease ameliorated by the inhibition of Flt3, or Flt3 and FAK.

8-ETHYL-6-(ARYL)PYRIDO [2,3-D]PYRIMIDIN-7(8H) -ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER

Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders such as neuropsychiatric disorders or neurofibromatosis. Also described herein are methods of utilizing PAK inhibitors for the treatment of cancer.

FAK INHIBITORS

A compound of the formula (I): where R1 or R2 is a cycle amine group and R5 is an aromatic group with a carbonyl containing substituent for use as a FAK inhibitor.